1. Central line-associated bloodstream infection trend in Brazilian adult intensive care units: an ecological study.
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Resende de Souza da Silva, Alexsandra Gomes, Bisinoto Alves, Sergiane, Resende Guimarães, Elisângela Eurípedes, Rodrigues Braga, Jessyca, Cunha Neves, Heliny Carneiro, Vieira dos Santos, Silvana de Lima, and Carmo Moreira, Maria Auxiliadora
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CENTRAL line-associated bloodstream infections , *KLEBSIELLA pneumoniae , *INTENSIVE care units , *MULTIDRUG resistance in bacteria , *CENTRAL venous catheters , *INTENSIVE care patients - Abstract
Introduction: Central line-associated bloodstream infections are the second most frequent infection in intensive care units. It represents an adverse event of significant magnitude, thus threatening the patient safety. The aim of this study was to analyze the historical trend of central line-associated bloodstream infections in patients in intensive care units, the rate of infection, central venous catheter utilization ratio, type of pathogen and their antimicrobial resistance pattern. Methodology: This ecological study was performed at 42 intensive care units from a state capital of the Midwest region of Brazil. Central lineassociated bloodstream infections notifications were collected from two databases, the Municipal Coordination for Patient Safety and Infection Control at Healthcare Services, from 2012-2016, and the FormSUS (National Health System Data Processing Company), from 2014-2016. Results: The incidence of central line-associated bloodstream infections was high and stationary in the period (incidence rate of 2.3 to 3.2 per 1,000 catheter days, central venous catheter utilization ratio average 56,9%). The most frequent microorganisms were coagulase-negative Staphylococcus, Klebsiella pneumoniae, Acinetobacter spp. and Pseudomonas aeruginosa. Resistance to 3rd and 4th generation cephalosporins and carbapenems were detected among Gram-negative bacteria, and resistance to oxacillin among Gram-positive bacteria. Conclusions: Central line-associated bloodstream infections incidence rates were high, however the historical trend remained stationary in adult intensive care units. Infections were mostly caused by coagulase-negative Staphylococcus, K. pneumoniae, Acinetobacter spp. and Pseudomonas aeruginosa, including multi-drug resistant organisms. These findings point to the need of educational strategies addressing the adherence to established preventive measures and to the rational use of antimicrobials. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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