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Multi-source interior computed tomography (CT) has a great potential to provide ultra-fast and organ-oriented imaging at low radiation dose. However, X-ray cross scattering from multiple simultaneously activated X-ray imaging chains compromises imaging quality. Previously, we published two hardware-based scatter correction methods for multi-source interior CT. Here, we propose a software-based scatter correction method, with the benefit of no need for hardware modifications. The new method is based on a physics model and an iterative framework. The physics model was derived analytically, and was used to calculate X-ray scattering signals in both forward direction and cross directions in multi-source interior CT. The physics model was integrated to an iterative scatter correction framework to reduce scatter artifacts. The method was applied to phantom data from both Monte Carlo simulations and physical experimentation that were designed to emulate the image acquisition in a multi-source interior CT architecture recently proposed by our team. The proposed scatter correction method reduced scatter artifacts significantly, even with only one iteration. Within a few iterations, the reconstructed images fast converged toward the “scatter-free” reference images. After applying the scatter correction method, the maximum CT number error at the region-of-interests (ROIs) was reduced to 46 HU in numerical phantom dataset and 48 HU in physical phantom dataset respectively, and the contrast-noise-ratio at those ROIs increased by up to 44.3% and up to 19.7%, respectively. The proposed physics model-based iterative scatter correction method could be useful for scatter correction in dual-source or multi-source CT. [ABSTRACT FROM PUBLISHER]

Purpose The schemes of multi-source interior computed tomography ( CT) have shown promise for ultra-fast, organ-oriented, and low-dose dynamic imaging. Besides forward scattering, x-ray cross scattering from multiple x-ray sources activated simultaneously can further degrade image quality. Here, we investigate the overall x-ray scattering artifact in a recently proposed multi-source interior CT architecture, and present two methods for scatter correction. Methods Compared to single-source global CT, scattering in multi-source interior CT architecture is affected by two new factors: cross scattering from simultaneously activated multiple x-ray sources and region-of-interest ( ROI) oriented interior CT mode. The scatter artifact in the multi-source interior CT architecture was evaluated through both numerical simulation and physical experimentation, and compared to that from conventional single-source global CT. Monte Carlo simulation was conducted with a modified numerical CATphan® 600 phantom. Physical experiments were performed in an in-house developed CT imaging platform with a custom-built phantom. The simulation and experiments were carried out on the single-source CT architecture and the multi-source CT architecture, respectively in the global CT mode and the interior CT mode for comparison. To correct the scattering artifact, two new methods were presented. The first is a beam-stopper-array ( BSA)-based method, which enables an online correction of forward scattering and cross scattering simultaneously. The second is a source-trigger-sequence ( STS)-based method dedicated to cross-scatter correction. It enables on-the-fly measurements of the cross scattering signals at a few pre-selected views. The CT image quality was quantitatively evaluated in terms of contrast-to-noise ratio ( CNR) and CT number deviation before and after the scatter correction. Results X-ray cross scattering degraded image quality in both the simulation and experiments. Before the scatter correction, the multi-source interior CT mode yielded a reduction of CNR at the ROIs by up to 68.5% and 50.7% in the simulation and experiments, respectively. The stationary BSA-based method significantly improved CNR and CT number accuracy in the images from multi-source interior CT mode, by reducing the negative effects from both forward scattering and cross scattering. The STS-based method enabled multi-source interior CT mode to provide comparable image quality to that with the single-source interior CT mode, by correcting the artifact from cross scattering. The remaining forward scattering artifact can be corrected with the fast adaptive scatter kernel superposition ( FASKS) technique. With the proposed scatter correction methods, the CT number error at the ROIs was reduced to less than 37 HU in both simulation and experiments, respectively. Conclusions Cross scattering, in addition to forward scattering, can cause significant image quality degradation in the multi-source interior CT architecture. However, image quality can be significantly improved with the proposed scatter correction methods. [ABSTRACT FROM AUTHOR]

Purpose: The size of field-of-view (FOV) of a microcomputed tomography (CT) system can be increased by offsetting the detector. The increased FOV is beneficial in many applications. All prior investigations, however, have been focused to the case in which the increased FOV after offset-detector acquisition can cover the transaxial extent of an object fully. Here, the authors studied a new problem where the FOV of a micro-CT system, although increased after offset-detector acquisition, still covers an interior region-of-interest (ROI) within the object. Methods: An interior-ROI-oriented micro-CT scan with an offset detector poses a difficult reconstruction problem, which is caused by both detector offset and projection truncation. Using the projection completion techniques, the authors first extended three previous reconstruction methods from offset-detector micro-CT to offset-detector interior micro-CT. The authors then proposed a novel method which combines two of the extended methods using a frequency split technique. The authors tested the four methods with phantom simulations at 9.4%, 18.8%, 28.2%, and 37.6% detector offset. The authors also applied these methods to physical phantom datasets acquired at the same amounts of detector offset from a customized micro-CT system. Results: When the detector offset was small, all reconstruction methods showed good image quality. At large detector offset, the three extended methods gave either visible shading artifacts or high deviation of pixel value, while the authors' proposed method demonstrated no visible artifacts and minimal deviation of pixel value in both the numerical simulations and physical experiments. Conclusions: For an interior micro-CT with an offset detector, the three extended reconstruction methods can perform well at a small detector offset but show strong artifacts at a large detector offset. When the detector offset is large, the authors' proposed reconstruction method can outperform the three extended reconstruction methods by suppressing artifacts and maintaining pixel values. [ABSTRACT FROM AUTHOR]

Spectral CT has proven an important development in biomedical imaging, and there have been several publications in the past years demonstrating its merits in pre-clinical and clinical applications. In 2012, Xu reported that near-term implementation of spectral micro-CT could be enhanced by a hybrid architecture: a narrow-beam spectral “interior” imaging chain integrated with a traditional wide-beam “global” imaging chain. This hybrid integration coupled with compressive sensing (CS)-based interior tomography demonstrated promising results for improved contrast resolution, and decreased system cost and radiation dose. The motivation for the current study is implementation and evaluation of the hybrid architecture with a first-of-its-kind hybrid spectral micro-CT system. Preliminary results confirm improvements in both contrast and spatial resolution. This technology is shown to merit further investigation and potential application in future spectral CT scanner design. [ABSTRACT FROM PUBLISHER]