1. Effect of continuous positive airway pressure on inflammatory, antioxidant, and depression biomarkers in women with obstructive sleep apnea: a randomized controlled trial
- Author
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Campos-Rodriguez, Francisco, Asensio-Cruz, Maria Isabel, Cordero-Guevara, Jose, Jurado-Gamez, Bernabe, Carmona-Bernal, Carmen, González Martínez, Mónica, Troncoso, Maria F., Sanchez-Lopez, Veronica, Arellano-Orden, Elena, Garcia-Sanchez, Maria Isabel, Martinez-Garcia, Miguel Angel, Spanish Sleep Network, Junta de Andalucía, Sociedad Española de Neumología y Cirugía Torácica, and Universidad de Cantabria
- Subjects
medicine.medical_treatment ,medicine.disease_cause ,Gastroenterology ,Antioxidants ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,Continuous positive airway pressure ,Depression (differential diagnoses) ,Sleep Apnea, Obstructive ,Continuous Positive Airway Pressure ,biology ,Depression ,Middle Aged ,biomarkers, continuous positive airway pressure, depression, inflammation, obstructive sleep apnea, oxidative stress, women ,Treatment Outcome ,Female ,Inflammation Mediators ,medicine.symptom ,medicine.medical_specialty ,Obstructive Sleep Apnea ,Inflammation ,03 medical and health sciences ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Women ,Interleukin 6 ,Aged ,business.industry ,medicine.disease ,Obstructive sleep apnea ,nervous system diseases ,respiratory tract diseases ,Oxidative Stress ,030228 respiratory system ,Oxidative stress ,biology.protein ,Neurology (clinical) ,business ,Body mass index ,030217 neurology & neurosurgery ,Biomarkers ,Follow-Up Studies - Abstract
Spanish Sleep Network., [Study Objectives] The effect of continuous positive airway pressure (CPAP) on mediators of cardiovascular disease and depression in women with obstructive sleep apnea (OSA) is unknown. We aimed to assess the effect of CPAP therapy on a variety of biomarkers of inflammation, antioxidant activity, and depression in women with OSA., [Methods] We conducted a multicenter, randomized controlled trial in 247 women diagnosed with moderate-to-severe OSA (apnea–hypopnea index [AHI] ≥ 15). Women were randomized to CPAP (n = 120) or conservative treatment (n = 127) for 12 weeks. Changes in tumor necrosis factor α (TNFα), interleukin 6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), catalase (CAT), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF) were assessed. Additional analyses were conducted in subgroups of clinical interest., [Results] Women had a median (25th–75th percentiles) age of 58 (51–65) years, body mass index 33.5 (29.0–38.3) kg/m2, and AHI 33.3 (22.8–49.3). No differences were found between groups in the baseline levels of the biomarkers. After 12 weeks of follow-up, there were no changes between groups in any of the biomarkers assessed. These results did not change when the analyses were restricted to sleepy women or to those with severe OSA. In women with CPAP use at least 5 hours per night, only TNFα levels decreased compared to the control group (−0.29 ± 1.1 vs −0.06 ± 0.53, intergroup difference −0.23 [95% CI = −0.03 to −0.50]; p = 0.043)., [Conclusions] Twelve weeks of CPAP therapy does not improve biomarkers of inflammation, antioxidant activity, or depression compared to conservative treatment in women with moderate-to-severe OSA., [Trial Registration] NCT02047071., This study was supported by a grant from the Consejería de Salud de la Junta de Andalucía (PI-0056-2016), and a grant from the Sociedad Española de Neumología y Cirugía Torácica SEPAR (19/2016).
- Published
- 2019