1. Interleukin-4 cytokine single nucleotide polymorphisms in kawasaki disease: a case-control study and a review of knowledge.
- Author
-
Assari R, Aghighi Y, Ziaee V, Sadr M, Rezaei A, Rahmani F, Sadr Z, Raeeskarami SR, Moradinejad MH, and Rezaei N
- Subjects
- Age Factors, Case-Control Studies, Child, Preschool, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Heterozygote, Homozygote, Humans, Infant, Interleukin-4 Receptor alpha Subunit genetics, Iran, Male, Mucocutaneous Lymph Node Syndrome diagnosis, Mucocutaneous Lymph Node Syndrome immunology, Phenotype, Risk Factors, Interleukin-4 genetics, Mucocutaneous Lymph Node Syndrome genetics, Polymorphism, Single Nucleotide
- Abstract
Aim: Kawasaki disease (KD) is a systemic vasculitis of medium-sized arteries. High levels of interleukin 4 (IL-4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL-4 and IL-4R gene polymorphisms were investigated in Iranian children with KD., Methods: Fifty-five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL-4 gene at positions -1098 (rs2243248), -590 (rs2243250) and -33 (rs2070874), as well as IL-4RA gene at position +1902 (rs180275) were assessed in patients and the control group., Results: The C allele and CC genotype of IL-4 gene at position -590 and at position -33 had positive associations and the CT genotype at -590 was negatively associated with KD (odds ratio (95% CI) = 0.04 [0.01-0.09]). The haplotype TCC was more frequent among the patients, while the haplotypes TTT and TTC had a negative association with KD., Conclusion: IL-4 polymorphisms might be associated with KD in an Iranian population., (© 2016 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
- Published
- 2018
- Full Text
- View/download PDF