1. Cord blood interleukin-6 and neonatal morbidities among preterm infants with PCR-positive Ureaplasma urealyticum.
- Author
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Hassanein SM, El-Farrash RA, Hafez HM, Hassanin OM, and Abd El Rahman NA
- Subjects
- Biomarkers blood, DNA, Bacterial analysis, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases diagnosis, Infant, Premature, Diseases etiology, Infant, Premature, Diseases immunology, Male, Polymerase Chain Reaction, Prospective Studies, ROC Curve, Respiratory Distress Syndrome, Newborn diagnosis, Respiratory Distress Syndrome, Newborn immunology, Respiratory Distress Syndrome, Newborn microbiology, Risk Factors, Sepsis diagnosis, Sepsis etiology, Sepsis immunology, Ureaplasma urealyticum genetics, Fetal Blood immunology, Fetal Blood microbiology, Infant, Premature, Diseases microbiology, Interleukin-6 blood, Sepsis microbiology, Ureaplasma Infections diagnosis, Ureaplasma Infections etiology, Ureaplasma Infections immunology, Ureaplasma urealyticum isolation & purification
- Abstract
Objectives: To evaluate the clinical significance of Ureaplasma urealyticum recovery from umbilical cord blood, using Polymerase Chain Reaction (PCR), and its association with umbilical cord interleukin-6 (IL-6) levels and neonatal morbidity in preterm infants., Methods: Cord blood PCR for Ureaplasma urealyticum, and IL-6 were assessed in relation to neonatal outcomes of 30 preterm deliveries of less than 35 weeks' gestation., Results: Ureaplasma urealyticum was present in 43.3% of the examined cord blood samples. Positive neonatal Ureaplasma urealyticum was more common in association with premature rupture of membranes, chorioamnionitis, antenatal maternal use of antibiotics, and earlier gestation. Ureaplasma urealyticum was also associated with an early pro-inflammatory immune response (i.e. elevated IL-6 and positive C-reactive protein). Cutoff level of interleukin-6 of 240 pg% predicts the occurrence of respiratory distress syndrome (RDS), in neonates with positive PCR for Ureaplasma urealyticum., Conclusions: Preterm patients with positive cord blood PCR for Ureaplasma urealyticum were more likely to have premature rupture of membrane, antenatal antibiotics, chorioamnionitis, earlier gestation, pro-inflammatory response, and RDS than those with a negative PCR. High IL-6 is more likely associated with RDS in Ureaplasma urealyticum positive neonates.
- Published
- 2012
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