1. [Impact of herpesvirus infections on the level of proinflammatory cytokines in premature neonatal infants].
- Author
-
Klimova RR, Malinovskaia VV, Guseva TS, Parshina OV, Getiia EG, Degtiareva MV, Soldatova IG, Volodin NN, Gadzhieva ZS, Tsibizov AS, and Kushch AA
- Subjects
- Biomarkers blood, Cytomegalovirus immunology, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Interferon alpha-2, Interferon-alpha administration & dosage, Leukocytes immunology, Leukocytes metabolism, Recombinant Proteins, Simplexvirus immunology, Suppositories administration & dosage, Suppositories therapeutic use, Cytomegalovirus Infections immunology, Cytomegalovirus Infections therapy, Herpesviridae Infections immunology, Herpesviridae Infections therapy, Interferon-alpha therapeutic use, Interferon-beta blood, Interferon-beta urine, Interleukin-6 blood, Interleukin-6 urine, Interleukin-8 blood, Interleukin-8 urine
- Abstract
The aim of this study was to estimate the frequency of HSV and/or CMV among the pathogens causing intrauterine infections (IUI) and to investigate their impact on the level of proinflammatory cytokines in premature neonatal infants. Examinations were performed in 3 neonatal groups: 1) premature neonates with clinical manifestations of IUI; 2) those without IUI; 3) full-term newborns. In group 1, viral (HSV and/or CMV) and bacterial infections were detectable with the same frequency. Quantitative analysis of plasma IL-6 and IL-8 levels and the induced production of these cytokines by blood cells in vitro showed that in Group 1 neonates, IL-6 and IL-8 concentrations were substantially higher and the induced production of these cytokines was lowerthan those in Group 3. The detection of HSV and/or CMV markers in premature newborn infants was attended by a statistically significant rise in plasma IL-6 levels; the identification of the opportunistic bacterial microflora correlated with the higher concentration of IL-8. In Group 1, wiferon produced an immunomodulatory effect, by lowering IL-8 concentrations to the level observed in Group 3.
- Published
- 2011