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Your search keyword '"Alain Benitez"' showing total 21 results
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21 results on '"Alain Benitez"'

1. Effect of topical swallowed steroids on the bacterial and fungal esophageal microbiota in eosinophilic esophagitis

Author

Casey E. Hofstaedter, Jonathan Gross, Ceylan Tanes, Dorothy Kim, Kyle Bittinger, Jonathan M. Spergel, Alain Benitez, Lisa M. Mattei, Amanda B. Muir, Lindsey Albenberg, and Melanie A. Ruffner

Subjects
medicine.medical_specialty, business.industry, Microbiota, Immunology, Eosinophilic Esophagitis, medicine.disease, Gastroenterology, Article, Internal medicine, medicine, Immunology and Allergy, Fluticasone, Humans, Steroids, Eosinophilic esophagitis, business
Published
2020

2. 601 A COMPARISON STUDY OF ESOPHAGOGASTRIC JUNCTION DISTENSIBILITY MEASUREMENT IN PEDIATRIC PATIENTS WITH ACHALASIA PRE- AND POST-DILATION, AND CONTROLS

Author

Petar Mamula, Alain Benitez, Cassandra Burger, Kristin Fiorino, Amanda B. Muir, Calies D. Menard-Katcher, and Stephen Budhu

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Achalasia, medicine.disease, Internal medicine, medicine, Comparison study, Cardiology, Dilation (morphology), Radiology, Nuclear Medicine and imaging, Esophagogastric junction, business, Pre and post
Published
2020
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4. Persistent Basal Cell Hyperplasia is Associated with Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis

Author

Kelly A. Whelan, Benjamin J. Wilkins, Okan U. Elci, Evan S. Dellon, Gary W. Falk, Jonathan Gross, Bridget Godwin, Andres J. Klein-Szanto, Hiroshi Nakagawa, Jonathan M. Spergel, Maureen DeMarshall, Amanda B. Muir, Medha Sharma, Alain Benitez, and Chris A. Liacouras

Subjects
medicine.medical_specialty, Adolescent, Basal Cell Hyperplasia, Gastroenterology, Article, 03 medical and health sciences, Leukocyte Count, 0302 clinical medicine, Internal medicine, medicine, Humans, Esophagus, Eosinophilic esophagitis, Hyperplasia, Hepatology, biology, medicine.diagnostic_test, business.industry, Esophagogastroduodenoscopy, Odds ratio, Eosinophilic Esophagitis, Eosinophil, medicine.disease, Eosinophils, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Major basic protein, biology.protein, 030211 gastroenterology & hepatology, business, Spongiosis
Abstract

Background & Aims Although eosinophil count is the standard used to monitor disease activity in patients with eosinophilic esophagitis (EoE), there are often disparities between patient-reported symptoms and eosinophil counts. We examined the prevalence of epithelial alterations, namely basal cell hyperplasia (BCH) and spongiosis, among patients with inactive EoE (eosinophil counts below 15 following therapy) and aimed to determine whether maintenance of these changes in epithelial morphology are associated with persistent clinical findings. Methods Esophageal biopsies of 243 patients (mean age, 16.9 years) undergoing routine endoscopy at the University of Pennsylvania were evaluated for epithelial BCH and spongiosis. Univariable analysis was used to calculate the association between epithelial changes and symptoms as well as endoscopic findings and peak eosinophil count. We validated our findings using data from a cohort of patients at the University of North Carolina. Results The discovery and validation cohorts each included patients with inactive EoE, based on histologic factors, but ongoing BCH and spongiosis. Ongoing BCH, but not spongiosis, in patients with inactive EoE was associated with symptoms (odds ratio, 2.14; 95% CI, 1.03–4.42; P = .041) and endoscopic findings (odds ratio, 7.10; 95% CI, 3.12–16.18; P Conclusions In patients with EoE, the presence of BCH might indicate ongoing disease activity, independent of eosinophil count. This might account for the persistent symptoms in patients who are considered to be in remission based on histologic factors.

Published
2019

6. Tu1968 SEVOFLURANE INFLUENCES ESOPHAGOGASTRIC JUNCTION DISTENSIBILITY IN THE ABSENCE OF ESOPHAGEAL INFLAMMATION

Author

Gary W. Falk, Calies Menard-Katcher, Svetlana Ostapenko, Alain Benitez, Denis H. Jablonka, Craig Gluckman, Varun Sahu, Maureen DeMarshall, Amanda B. Muir, and Kristle L. Lynch

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, Inflammation, Esophagogastric junction, medicine.symptom, business, Sevoflurane, medicine.drug
Published
2019
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10. Sa1124 - Esophagogastric Junction Distensibility is Decreased in Eosinophilic Esophagitis: Results from a Multicenter Pediatric Cohort

Author

Cynthia Li, Rossella Turco, Faria N. Ahmed, Calies Menard-Katcher, Jonathan Gross, Ritu Verma, Kristle L. Lynch, Alain Benitez, and Amanda B. Muir

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Cohort, Gastroenterology, medicine, Esophagogastric junction, business, Eosinophilic esophagitis, medicine.disease
Published
2018
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14. 68 Esophageal Distensibility Provides Measure of Remodeling in Pediatric Eosinophilic Esophagitis

Author

Ritu Verma, Jonathan M. Spergel, Robert E. Kramer, Chris A. Liacouras, Calies Menard-Katcher, Faria N. Ahmed, Amanda B. Muir, Alain Benitez, Hiroshi Nakagawa, and Glenn T. Furuta

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Measure (physics), Eosinophilic esophagitis, medicine.disease, business
Published
2016
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15. Persistent Basal Cell Hyperplasia in Patients with Inactive Eosinophilic Esophagitis: A New Tool for Understanding a Poorly Defined Population

Author

Kelly A. Whelan, Evan S. Dellon, Benjamin J. Wilkins, Gary W. Falk, Jonathan Gross, Hiroshi Nakagawa, Andres J. Klein-Szanto, Jonathan M. Spergel, Bridget Godwin, Okan U. Elci, Alain Benitez, Maureen DeMarshall, and Amanda B. Muir

Subjects
medicine.medical_specialty, Pathology, education.field_of_study, Hepatology, business.industry, Population, Gastroenterology, medicine.disease, Basal Cell Hyperplasia, Internal medicine, medicine, In patient, Eosinophilic esophagitis, education, business
Published
2017
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18. Age-Associated Decline in Esophageal Autophagy Flux Contributes to Fibrosis in Eosinophilic Esophagitis

Author

Maureen DeMarshall, Kelly A. Whelan, Jonathan Gross, Jonathan M. Spergel, Amanda B. Muir, Andres J. Klein-Szanto, Medha Sharma, Benjamin J. Wilkins, Gary W. Falk, Bridget Godwin, Alain Benitez, Prasanna M. Chandramouleeswaran, and Hiroshi Nakagawa

Subjects
medicine.medical_specialty, Hepatology, Fibrosis, business.industry, Internal medicine, Autophagy, Gastroenterology, medicine, Eosinophilic esophagitis, medicine.disease, business, Flux (metabolism)
Published
2017
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19. Mo1208 Esophageal Epithelial Autophagy Flux Regulates Eosinophilic Esophagitis Disease Activity

Author

Jianwen Que, Alain Benitez, Bridget Godwin, Joanne C. Masterson, Amanda B. Muir, Glenn T. Furuta, Kelly A. Whelan, Jamie Merves, Jonathan M. Spergel, Veronique Giroux, and Hiroshi Nakagawa

Subjects
medicine.medical_specialty, Hepatology, business.industry, Autophagy, Gastroenterology, medicine.disease, Disease activity, Internal medicine, medicine, Cancer research, Eosinophilic esophagitis, business, Flux (metabolism)
Published
2016
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21. Su1178 Matrix-Stiffness Enhances Esophageal Fibroblast Activation, Proliferation and Contractility in Pediatric and Adult Fibroblasts

Author

Kara K. Dods, Amanda B. Muir, Gary W. Falk, Daniel A. Hammer, Alain Benitez, Steven J. Henry, Hiroshi Nakagawa, Rebecca G. Wells, Mei-Lun Wang, and Maureen DeMarshall

Subjects
Medical food, medicine.medical_specialty, education.field_of_study, Hepatology, business.industry, Population, Gastroenterology, Frequent stools, Matrix (biology), Contractility, Pediatric patient, medicine.anatomical_structure, Internal medicine, Antibiotic therapy, medicine, business, education, Fibroblast
Abstract

of SBI in a pediatric patient with an acute diarrhea due to SIBO and/or antibiotic therapy. SBI may prove to be useful in some acute setting where limited therapeutic options are available. Given that SBI has been designated as a medical food with GRAS (General Recognized As Safe) status for use in the general population, it may serve as an option for children in the nutritional management of chronic loose and frequent stools.

Published
2015
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