1. Burden of arrhythmia in hospitalized HIV patients
- Author
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Vaibhav R. Vaidya, Shilpkumar Arora, Siva K. Mulpuru, Anas Abudan, Peter A. Noseworthy, Christopher V. DeSimone, Byomesh Tripathi, Abhishek Deshmukh, Haarini Sridhar, Daniel C. DeSimone, and Alexander C. Egbe
- Subjects
Adult ,Male ,medicine.medical_specialty ,Demographics ,Adolescent ,Databases, Factual ,Human immunodeficiency virus (HIV) ,Clinical Investigations ,HIV Infections ,Comorbidity ,030204 cardiovascular system & hematology ,medicine.disease_cause ,arrhythmia ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,In patient ,030212 general & internal medicine ,cardiovascular diseases ,Hospital Mortality ,Aged ,Aged, 80 and over ,Inpatients ,business.industry ,Mortality rate ,HIV ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,United States ,Hospitalization ,human immunodeficiency virus (HIV) ,Quartile ,frequency ,Life expectancy ,Hiv patients ,cardiovascular system ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The improved life expectancy observed in patients living with human immunodeficiency virus (HIV) infection has made age‐related cardiovascular complications, including arrhythmias, a growing health concern. Hypothesis We describe the temporal trends in frequency of various arrhythmias and assess impact of arrhythmias on hospitalized HIV patients using the Nationwide Inpatient Sample (NIS). Methods Data on HIV‐related hospitalizations from 2005 to 2014 were obtained from the NIS database using International Classification of Diseases, 9th Revision (ICD‐9) codes. Data was further subclassified into hospitalizations with associated arrhythmias and those without. Baseline demographics and comorbidities were determined. Outcomes including in‐hospital mortality, cost of care, and length of stay were extracted. SAS 9.4 (SAS Institute Inc., Cary, NC) was utilized for analysis. A multivariable analysis was performed to identify predictors of arrhythmias among hospitalized HIV patients. Results Among 2 370 751 HIV‐related hospitalizations identified, the overall frequency of any arrhythmia was 3.01%. Atrial fibrillation (AF) was the most frequent arrhythmia (2110 per 100 000). The overall frequency of arrhythmias increased over time by 108%, primarily due to a 132% increase in AF. Arrhythmias are more frequent among older males, lowest income quartile, and nonelective admissions. Patients with arrhythmias had a higher in‐hospital mortality rate (9.6%). In‐hospital mortality among patients with arrhythmias decreased over time by 43.8%. The cost of care and length of stay associated with arrhythmia‐related hospitalizations were mostly unchanged. Conclusions Arrhythmias are associated with significant morbidity and mortality in hospitalized HIV patients. AF is the most frequent arrhythmia in hospitalized HIV patients.
- Published
- 2020