1. Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
- Author
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Rodilla Sala, Enrique, López Carmona, Maria Dolores, Cortes, Xavi, Cobos Palacios, Lidia, Canales, Sergio, Sáez, Maria Carmen, Campos Escudero, Samara, Rubio-Rivas, Manuel, Díez Manglano, Jesús, Freire Castro, Santiago, Vázquez Piqueras, Nuria, Mateo Sanchis, Elisabeth, Pesqueira Fontan, Paula Maria, Magallanes Gamboa, Jeffrey Oskar, González García, Andrés, Madrid Romero, Victor, Tamargo Chamorro, Lara, González Moraleja, Julio, Villanueva Martínez, Javier, González Noya, Amara, Suárez Lombraña, Ana, Gracia Gutiérrez, Anyuli, López Reboiro, Manuel Lorenzo, Ramos Rincón, José Manuel, Gómez Huelgas, Ricardo, and SEMI-COVID-19 Network
- Subjects
Male ,heart failure ,Blood Pressure ,Comorbidity ,Kaplan-Meier Estimate ,Insuficiència cardíaca ,030204 cardiovascular system & hematology ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,blood pressure ,Cause of Death ,Epidemiology ,Odds Ratio ,Hospital Mortality ,Registries ,030212 general & internal medicine ,Cause of death ,Aged, 80 and over ,Age Factors ,Middle Aged ,Prognosis ,arterial stiffness ,Cardiovascular diseases ,Cardiovascular Diseases ,Female ,COVID-19 ,hypertension ,medicine.medical_specialty ,Heart failure ,pulse pressure ,03 medical and health sciences ,Vascular Stiffness ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Obesity ,Pandemics ,Aged ,Retrospective Studies ,SARS-CoV-2 ,business.industry ,Malalties cardiovasculars ,Retrospective cohort study ,Original Articles ,Odds ratio ,medicine.disease ,Blood pressure ,Spain ,Arterial stiffness ,business - Abstract
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) P P =0.0001; ORadj: 1.48, P =0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P =0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P =0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P =0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP
- Published
- 2021