Search

Objective Watching if long acting testosterone added to sildenafil can maintain improved sexual life, reflected by a longest erectile capability and sexual desire, in erectile dysfunction (ED) associated with metabolic syndrome (MetS). Design and method In 49 men with MetS (NCEP-ATP III criteria) ED was assessed (V1) using IIEF questionnaire and its domains: erectile function (EF) and sexual desire (SD). ED was treated by sildenafil citrate (S) in 2-4 tb. of 50 mg/week for 2 months. Group A = 24 participants receiving also a long acting testosterone (T) injection. Group B = 25 cases treated only with sildenafil. At 10 days (V2) and 30 days (V3) and immediate (V2) and at 30 days (V3) after S end usage EF and SD respectively were assessed. Results IIEF (V1): Gr. A vs. Gr. B = 44.16 vs. 43.67 points (p). EF domain scores: Gr. A: V1=16.2 p; V2=26.34 p (P=0.002); V3=20.89 p (P=0.07). Gr. B: V1=14.1 p; V2=23.3 (P=0.001); V3=15.9 (P=0.5). V2: Gr. A vs. Gr. B=26.34 vs. 23.3 (P=0.45). V3: Gr. A vs. Gr. B=20.89 vs. 15.9 (P=0.07). SD domain scores: Gr. A: V1=4.7 p; V2=8.9 p (P=0.001); V3=8.5 p (P=0.08). Gr. B: V1=5.7 p; V2=9.1 p (P=0.002); V3=4.9 p (P=0.15). V2: Gr. A vs. Gr. B=8.9 vs. 9.1 (P=0.6); V3: Gr. A vs. Gr. B=8.5 vs. 4.9 (P=0.001). Conclusions Long acting testosterone really improve sexual life by prolonging a satisfying prevalence of non phosphodiesteraze-5 inhibitor induced erections and maintaining sexual desire after sildenafil usage.

We have studied kidney samples of 16 garden dormouses (Eliomys quercinus L.) divided into two groups, 8 hibernating and 8 non-hibernating. Hibernation produces structural modifications in the glomerular ultrafilter: (1) the endothelial pores decrease in number and size; (2) the podocytic food processes increase in number and the slit pores decrease in size; (3) in the basement membrane there are no structural morphological modifications. In short, we could say that the permeability of the glomerular ultrafilter decreases during hibernation. This fact helps to understand the decrease in the rate of urine formation that takes place in the presence of a low body temperature and a metabolic depression.

We have carried out an ultrastructural study of the proximal convoluted kidney tubule in hibernating and nonhibernating garden dormice. Deep hibernation produced the following changes: the nuclei had an irregular shape; saccular cavities appeared near the nucleus and there was an increase in the components of the lysosomal system; hibernation seems to have no influence on the number of mitochondria; hypertrophic mitochondria occur in controls, whereas none were ever seen in hibernating dormice.