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This is the framing paper for a special journal issue on this topic. The paper and issue interrogate transnational legal orders and their impacts (material, institutional and normative) on domestic law and practice. The paper provides a framework for assessing the interrelation of the international, transnational and national levels, with international and transnational initiatives taking from state models which reflect interests and institutional and normative legacies, and with these initiatives confronting national contexts which generate responses which, in turn, feed back into the international and transnational levels in a recurrent manner. The method used is to build from case studies which start with an issue and a regulatory space that involve either more than one country or more than one legal regime, interrogate the impact of transnationalism and its limits and its effects within states, and then draw inductively from these studies. ..PAT.-Unpublished Manuscript [ABSTRACT FROM AUTHOR]