1. Similar α-Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls.
- Author
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Antunes L, Frasquilho S, Ostaszewski M, Weber J, Longhino L, Antony P, Baumuratov A, Buttini M, Shannon KM, Balling R, and Diederich NJ
- Subjects
- Aged, Biomarkers metabolism, Female, Humans, Male, Middle Aged, Colon metabolism, Intestinal Mucosa metabolism, Parkinson Disease metabolism, alpha-Synuclein metabolism
- Abstract
Background: The gut is proposed as a starting point of idiopathic IPD, but the presence of α-synuclein in the IPD colon mucosa is debated., Objectives: The objective of this study was to evaluate if α-synuclein in the colon mucosa can serve as a biomarker of IPD., Methods: Immunohistochemistry was used to locate and quantify in a blinded approach α-synuclein in the mucosa from biopsies of the right and left colon in 19 IPD patients and 8 controls., Results: Total α-synuclein was present in all but 1 IPD patients and in all controls; phosphorylated α-synuclein was present in all subjects. There was no intensity difference depending on disease status. Staining of total α-synuclein was stronger in the right colon (p = .04)., Conclusions: Conventional immunohistochemistry α-synuclein staining in colon mucosal biopsies cannot serve as a biomarker of idiopathic PD. These findings do not contradict the assumption of disease starting in the colon, and a colon segment-specific risk for disease initiation can still be hypothesized. © 2016 International Parkinson and Movement Disorder Society., (© 2016 International Parkinson and Movement Disorder Society.)
- Published
- 2016
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