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Introduction and purpose: Baclofen is a derivative of γ-aminobutyric acid (GABA). It is a spasmolytic drug that reduces skeletal muscle tension and is used in spasticity. Despite its many positive functions, its use is associated with a risk of side effects. The aim of this work is to gain a better understanding of baclofen and to highlight the toxicity and dangers of its misuse. Material and methods: The study was retrospective in nature. It used an analysis of the records of 11648 intoxications in patients hospitalised from 01.04.2013 to 01.04.2023 in the Clinical Toxicology and Cardiology Department of the Stefan Cardinal Wyszyński Provincial Hospital in Lublin, from which a group of baclofen intoxicated patients (T55), consisting of 19 cases, was distinguished. Results: The study population consisted of 10 women (52.63%) and 9 men (47.37%), aged between 16 and 83 years. The largest group consisted of patients aged up to 30 years - 9 patients (47.37%). The majority of patients - 11 patients (59.89%) were in a severe condition. An overwhelming number reported intentional poisoning - 16 cases (84.21%), including five suicide attempts (31.25%). Patients took other drugs and medicines in addition to baclofen. The most common was ethanol - 8 people (42.11%), followed by NSAIDs - 5 people (26.32%). Conclusions: In order to prevent complications following the use of baclofen, it is very important to educate patients, their family members and the general public about the mechanism of action of the drug itself, its function on the body and the risks of taking it. Prophylactic measures and education on how to deal with poisoning situations are necessary, as they are entirely preventable with immediate diagnosis and treatment.

Introduction: Poisonings with non-beverage alcohols remain a significant problem in contemporary toxicology. Due to the large quantity and severe course of intoxications with methanol, the authors of this study focused primarily on poisonings with this substance. Methanol is widely used in industry. Its toxicity is attributed to its metabolites - formaldehyde and formic acid. Poisonings with methanol often lead to the patient's death due to a wide range of complications associated with progressive metabolic acidosis. Material and Methods: The study is of a retrospective nature. It involved the analysis of medical records of patients admitted to the department of toxicology in 2022 after the consumption of non-beverage alcohols, with a particular focus on methanol. Data on the number of individuals admitted due to non-beverage alcohol intoxication between 2018 and 2022 was also analyzed. Results: Over the last 5 years (2018-2022), 36 individuals were hospitalized in the Clinical Toxicological-Cardiological Department due to non-beverage alcohol poisoning, with 16 (44.4%) cases involving methanol. In the year 2022, the department admitted 10 individuals aged 18 to 68, and 5 (50%) of them consumed methanol. Among the hospitalized, 90% were male, and 60% came from rural areas. Deliberate intoxications accounted for 70% of the cases. Four hospitalizations (40%) resulted in patient death. All deaths were associated with methanol intoxication. Conclusions: Non-beverage alcohol is often used by people with alcohol dependence syndrome. Among non-beverage alcohols, patients most often reached for methanol. Its consumption is associated with a high mortality rate and should be taken very seriously and treated immediately.

Introduction and purpose: Alcohol has been known for centuries. In recent years, awareness of the effects of its consumption has been growing and acceptance of the drink has been declining. Despite this, there is an increase in young alcohol consumption and a decrease in the age of alcohol initiation. In this work, the problem of alcohol consumption by minors will be reviewed based on the evaluation of hospitalizations in the Clinical Department of Toxicology and Cardiology of the Stefan Cardinal Wyszynski Regional Hospital in Lublin in 2022. The aim of the study is to draw attention to this important, although often downplayed, problem. Material and method: The study was retrospective in nature. It used an analysis of the records of 120 intoxications in people under the age of 18, from which a group of alcohol-poisoned people was distinguished, consisting of 37 cases. Results: Hospitalization of 7 patients aged 13 to 18 years was reported due to alcohol intoxication. Of these, 22 (59.5%) female and 15 (40.5%) male patients were singled out. Most were urban residents 29 (78.4%). Isolated alcohol intoxication was the cause of 18 hospitalizations(48.6%). The remaining cases were accompanied by drug intoxication 11 hospitalizations (29.7%) and drug intoxication 8 hospitalizations (21.6%). All analyzed intoxications were intentional, of which 9 (24.3%) were suicide attempts. In 14 cases (37.9%), patients were burdened with mental illness, the most common of which was depressive disorders. There were no deaths in the study group. Conclusions: Alcohol should be forbidden and unacceptable in the family and young people's environment. Parents and young people should be made aware of the harmful effects, psychological, social and health consequences of its consumption.