6 results on '"Zhao, You"'
Search Results
2. High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery
- Author
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Zhao-You Tang, Xin-Rong Yang, Xin Zhang, Yun-Fan Sun, Zheng Wang, Jian Zhou, Wenxin Qin, Shuang-Jian Qiu, Kai Zhu, Ruo-Yu Shi, Qiujin Shen, Jia Fan, Yang Xu, and Liu-Xiao Yang
- Subjects
Male ,musculoskeletal diseases ,Cancer Research ,Pathology ,medicine.medical_specialty ,Vascular Endothelial Growth Factor C ,MMP9 ,Metastasis ,Cholangiocarcinoma ,Cell Movement ,Cell Line, Tumor ,Humans ,Medicine ,Neoplasm Invasiveness ,Intrahepatic Cholangiocarcinoma ,Cell Proliferation ,Tissue microarray ,business.industry ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,Matrix Metalloproteinase 9 ,Oncology ,DKK1 ,Vascular endothelial growth factor C ,Lymphatic Metastasis ,Cancer research ,Intercellular Signaling Peptides and Proteins ,Immunohistochemistry ,Female ,business - Abstract
BACKGROUND: Dickkopf-related protein 1 (DKK1) has been reported involved in metastasis and invasion in several tumors. This study sought to investigate the prognostic value of DKK1 in intrahepatic cholangiocarcinoma (ICC) and its role in promoting ICC metastasis. METHODS: Tissue microarrays of 138 ICC patient samples were employed to detect DKK1, vascular endothelial growth factor C (VEGF-C), and matrix metalloproteinase 9 (MMP9) expression using immunohistochemistry. The prognostic significances were assessed by Kaplan-Meier survival estimates. DKK1 expression was measured in an ICC cell line (HCCC-9810) and ICC tissues by immunofluorescence assay, quantitative real-time polymerase chain reaction, and western blot. Serum levels of DKK1 from 37 ICC patients were tested by enzyme-linked immunosorbent assay. The role of DKK1 in proliferation, migration, invasion, and gene expression regulation was assessed by DKK1 depletion using small interfering RNA. RESULTS: Multivariate analyses revealed that DKK1 was an unfavorable predictor for overall survival and time to recurrence. The prognostic significance was retained in ICC patients with low recurrence risk (P < .05). DKK1 expression was elevated in an ICC cell line, tumor samples, and patient sera. High levels of DKK1 in ICC tissues correlated with elevated MMP9, VEGF-C, and metastasis of hepatic hilar lymph nodes. DKK1 depletion caused a decrease in cell migration and invasiveness, and down-regulation of MMP9 and VEGF-C expression. CONCLUSIONS: DKK1 is a novel prognostic biomarker for ICC, and it enhances tumor cell invasion and promotes lymph node metastasis of ICC through the induction of MMP9 and VEGF-C. DKK1 may be a potential therapeutic target for ICC. Cancer 2013. © 2012 American Cancer Society.
- Published
- 2012
3. Benefit of radiotherapy for 90 patients with resected intrahepatic cholangiocarcinoma and concurrent lymph node metastases
- Author
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Mengsu Zeng, Jian-Ying Zhang, Jia Fan, Wei Jiang, Yi-Xing Chen, Jian Zhou, Zhao-You Tang, Zhao-Chong Zeng, and Yunshan Tan
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Cholangiocarcinoma ,Internal medicine ,medicine ,Humans ,External beam radiotherapy ,Lymph node ,Survival analysis ,Intrahepatic Cholangiocarcinoma ,Hematology ,business.industry ,Cancer ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Surgery ,Radiation therapy ,Bile Ducts, Intrahepatic ,Treatment Outcome ,medicine.anatomical_structure ,Bile Duct Neoplasms ,Oncology ,Lymphatic Metastasis ,Female ,Lymph ,Radiology ,business ,Follow-Up Studies - Abstract
To evaluate the role of radiotherapy for patients with resected intrahepatic cholangiocarcinoma with concurrent macroscopic abdominal lymph node metastases. We identified 90 patients with resected intrahepatic cholangiocarcinoma and concurrent regional lymph node metastases treated between 1999 and 2008, thereinto 24 patients received local limited external beam radiotherapy (classified as the radiotherapy group) with a median total dose of 50 Gy (range 34–60 Gy) in fractions of 2 Gy five times a week. The remaining 66 patients did not receive external beam radiotherapy (classified as the non-radiotherapy group). We studied survival and tumor response to radiotherapy, demonstrated by symptoms and results of imaging, by Kaplan–Meier method and Cox analysis. After radiotherapy, lymph nodes showed partial response in nine patients (37.5%) and complete response in nine patients (37.5%). Median survival was 19.1 months in the radiotherapy group and 9.5 months in the non-radiotherapy group (P = 0.011). Multivariate analysis showed that increasing age, multiple intrahepatic primary tumors, higher level of CA19-9, and non-radiotherapy group were related to a poorer prognosis. The most common cause of death was intrahepatic recurrence, and death resulting from lymph node-related complications was similar between the two groups. External beam radiotherapy seems to improve the prognosis of patients with resected intrahepatic cholangiocarcinoma and concurrent macroscopic lymph node metastases.
- Published
- 2010
4. Staging, prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma after curative resection.
- Author
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Li, Tao, Qin, Lun ‐ Xiu, Zhou, Jian, Sun, Hui ‐ Chuan, Qiu, Shuang ‐ Jian, Ye, Qing ‐ Hai, Wang, Lu, Tang, Zhao ‐ You, and Fan, Jia
- Subjects
IMMUNOLOGICAL adjuvants ,SURGICAL excision ,CANCER invasiveness ,METASTASIS ,LYMPH nodes ,BLOOD plasma - Abstract
Background & Aims Prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma ( ICC) after curative resection were not clear. We aim to analyse prognostic factors after curative resection and evaluate adjuvant therapy and survival based on the new staging system. Methods A retrospective analysis of 283 patients who underwent surgical exploration for ICC was performed. Staging was performed according to the 7th edition AJCC staging manual. Univariate and multivariate analyses were used to evaluate independent prognostic factors. Results The difference for OS at different TNM stages after R0 resection was significant ( P < 0.001). Despite regional lymph node metastasis, tumour number and vascular invasion, serum GGT level was also an independent prognostic factor for OS of patients after R0 resection. The incidence of biliary and vascular invasion was significantly higher in high GGT group than in normal GGT group. Factors predictive of recurrence were multiple tumours and regional lymph node metastasis. After R0 resection, adjuvant TACE not only did not improve the OS of patients at TNM stage I ( P = 0.508), but significantly promoted recurrence of these patients ( P = 0.006). Only patients at TNM stage II, III and IV benefited from adjuvant TACE for longer survival, while the recurrence rates were not affected. Conclusions The new staging system can predict the survival of ICC patients after R0 resection. High GGT level may be suggestive of biliary and vascular invasion and was an independent risk factor for OS after R0 resection. Adjuvant TACE may be indicated only for patients at advanced stages for better survival. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
5. High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery.
- Author
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Shi, Ruo‐Yu, Yang, Xin‐Rong, Shen, Qiu‐Jin, Yang, Liu‐Xiao, Xu, Yang, Qiu, Shuang‐Jian, Sun, Yun‐Fan, Zhang, Xin, Wang, Zheng, Zhu, Kai, Qin, Wen‐Xin, Tang, Zhao‐You, Fan, Jia, and Zhou, Jian
- Subjects
CHOLANGIOCARCINOMA ,LYMPHATIC metastasis ,VASCULAR endothelial growth factors ,MATRIX metalloproteinases ,POLYMERASE chain reaction ,PROGNOSIS - Abstract
BACKGROUND: Dickkopf-related protein 1 (DKK1) has been reported involved in metastasis and invasion in several tumors. This study sought to investigate the prognostic value of DKK1 in intrahepatic cholangiocarcinoma (ICC) and its role in promoting ICC metastasis. METHODS: Tissue microarrays of 138 ICC patient samples were employed to detect DKK1, vascular endothelial growth factor C (VEGF-C), and matrix metalloproteinase 9 (MMP9) expression using immunohistochemistry. The prognostic significances were assessed by Kaplan-Meier survival estimates. DKK1 expression was measured in an ICC cell line (HCCC-9810) and ICC tissues by immunofluorescence assay, quantitative real-time polymerase chain reaction, and western blot. Serum levels of DKK1 from 37 ICC patients were tested by enzyme-linked immunosorbent assay. The role of DKK1 in proliferation, migration, invasion, and gene expression regulation was assessed by DKK1 depletion using small interfering RNA. RESULTS: Multivariate analyses revealed that DKK1 was an unfavorable predictor for overall survival and time to recurrence. The prognostic significance was retained in ICC patients with low recurrence risk ( P < .05). DKK1 expression was elevated in an ICC cell line, tumor samples, and patient sera. High levels of DKK1 in ICC tissues correlated with elevated MMP9, VEGF-C, and metastasis of hepatic hilar lymph nodes. DKK1 depletion caused a decrease in cell migration and invasiveness, and down-regulation of MMP9 and VEGF-C expression. CONCLUSIONS: DKK1 is a novel prognostic biomarker for ICC, and it enhances tumor cell invasion and promotes lymph node metastasis of ICC through the induction of MMP9 and VEGF-C. DKK1 may be a potential therapeutic target for ICC. Cancer 2013. © 2012 American Cancer Society. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
6. Intrahepatic cholangiocarcinoma: report of 272 patients compared with 5,829 patients with hepatocellular carcinoma.
- Author
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Xin-Da Zhou, Zhao-You Tang, Jia Fan, Jian Zhou, Zhi-Quan Wu, Lun-Xiu Qin, Zeng-Chen Ma, Hui-Chuan Sun, Shuang-Jian Qiu, Yao Yu, Ning Ren, Qing-Hai Ye, Lu Wang, and Sheng-Long Ye
- Subjects
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CANCER patients , *CANCER invasiveness , *SURGICAL excision , *ONCOLOGY ,TUMOR surgery - Abstract
To clarify clinicopathologic differences between patients with intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC), and identify potential factors influencing survival after hepatectomy for ICC. Comparison of clinicopathologic data was made between patients who underwent hepatectomy for ICC ( n = 272) and HCC ( n = 5,829) during the same period. Twenty-five clinicopathologic variables were selected for univariate and multivariate analyses to evaluate their influence on prognosis of ICC. Compared with patients with HCC, ICC patients were more common in females and more elderly, had a lower proportion of asymptomatic tumors, lower serum alpha-fetoprotein, higher serum carcinoembryonic antigen, carbohydrate antigen 19–9 and alkaline phosphatase levels; lower incidence of hepatitis history, associated cirrhosis and serum hepatitis B surface antigen; lower proportion of small tumors, well-encapsulated tumors and tumor emboli in the portal vein; higher proportion of single tumor, perihila lymph node involvement and poor differentiation; and less frequency of limited resection (all, P < 0.0001). Distant metastasis was less frequent in patients with ICC ( P = 0.027). A total of 5-years overall and disease-free survival (in brackets) after resection was 26.4% (13.1%) and 44.5% (33.1%) ( P < 0.0001, P < 0.0001) for patients with ICC and HCC, respectively. Factors influencing survival after resection of ICC can be divided mainly into two categories: early detection of asymptomatic ICC ( P < 0.0001) and curative resection ( P = 0.002). ICC Patients have distinct clinicopathologic features as compared with HCC patients. Surgery remains the only effective treatment for ICC. Early detection of asymptomatic ICC and curative resection were the key to achieve optimal survival. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
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