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Background/aim: To examine the relationship between baseline blood flow biomarkers and long-term open-angle glaucoma (OAG) progression., Methods: 112 patients with early to moderate OAG (mean age 64.9±11.0 years; 68 female) were evaluated at baseline and every 6 months from 2008 to 2013. Biomarkers of retinal capillary blood flow were assessed by Heidelberg retinal flowmetry. Functional disease progression was monitored via Humphrey visual field examinations, defined as two consecutive visits with a mean deviation decrease ≥2 decibels and/or Advanced Glaucoma Intervention Study score increase ≥2 compared with baseline. Structural progression was monitored with optical coherence tomography and Heidelberg retinal tomograph, defined as two consecutive visits with retinal nerve fibre layer thickness decrease ≥8% and/or horizontal or vertical cup/disk ratio increase ≥0.2 compared with baseline. Mixed-model analysis of covariance was used to test for significant change from baseline to 5-year follow-up. Times to functional and structural progression were analysed using Cox proportional hazards models., Results: Lower HRF retinal capillary blood flow in the superior retina was significantly associated with structural progression (p=0.0009)., Conclusion: In our OAG sample, baseline lower retinal capillary perfusion in the superior retina was predictive of structural progression after 5 years., Trial Registration Number: NCT01145911., Competing Interests: Competing interests: There are no competing interests. Professor Alon Harris would like to disclose that he received remuneration from AdOM, Qlaris, Cipla for serving as a consultant, and he serves on the board of AdOM and Qlaris. Professor Alon Harris holds an ownership interest in AdOM, Oxymap, Qlaris and SlitLed. All relationships listed above are pursuant to Icahn School of Medicine’s policy on outside activities. The contribution of the author Francesco Oddone was supported by Fondazione Roma and by the Italian Ministry of Health. None of the other authors listed have any financial disclosures., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)

Background/aim: Blood flow deficiencies of the retinal and retrobulbar circulations have been previously reported in open-angle glaucoma (OAG) and other eye diseases. Herein we investigated the effects of image brightness and contrast dynamic altering stimuli (DAS) when viewing a video content on ocular blood flow, intraocular pressure (IOP) and ocular perfusion pressure (OPP) in OAG and healthy subjects., Methods: Thirty-five subjects, 25 with OAG (mild to moderate) and 10 healthy controls, were evaluated for blood pressure, IOP, OPP and retinal capillary blood flow before, immediately after, 30 min after and 60 min after using ReviView (a dichoptic video goggles device), which stimulates one eye with a DAS video image that is brighter and with greater contrast than the fellow eye (duration of exposure 30 min). Differences between each subject's eyes and between OAG and healthy subjects were evaluated using repeated-measures analysis of variance with p<0.05 considered statistically significant., Results: All subjects demonstrated a significant increase in OPP in both eyes immediately following viewing. In all DAS eyes, retinal capillary blood flow rose immediately after stimulation and remained elevated for an hour postviewing. Viewing DAS increased retinal blood flow compared with control eyes (p=0.0014, 0.0135 superiorly and p=0.0094, 0.0001 inferiorly, at 30 and 60 min, respectively). OAG eyes had a significant reduction in the number of dormant retinal capillaries (p=0.0174), while healthy eyes demonstrated a larger increase in retinal capillary blood flow (p=0.0006 and p=0.0093 at 60 min, superior and inferior, respectively) following DAS viewing., Conclusion: Viewing DAS video for 30 min using ReviView increased retina blood flow both in healthy subjects and in patients with OAG., Trial Registration Number: NCT02959593., Competing Interests: Competing interests: AH would like to disclose that he receives remuneration from CIPLA, AdOM and Shire for serving as a consultant. AH also holds an ownership interest in AdOM and Oxymap. All relationships listed above are pursuant to Indiana University’s policy on outside activities.​ The contribution of ACVV was supported by Fondazione Roma and by the Italian Ministry of Health., (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.)

Purpose to compare scanning laser polarimetry (GDx) variable corneal compensation (VCC) and enhanced corneal compensation (ECC) in glaucoma suspects divided on the basis of lens conditions Methods 339 eyes of 182 consecutive patients were selected and submitted to complete ophthalmic evaluation, automated perimetry (HFA 24‐2), scanning laser polarimetry of RNFL with GDx VCC and ECC. Patients were divided into 4 groups if pseudophakic (IOL) or with different lens opacities graded according to LOCS‐III (NO/NC 1, 2 or 3). Morphometric parameters as TSNIT average, superior, inferior, nerve fiber indicator(NFI); quality of the image (Q)and typical scan score(TSS) given by the two GDx algorithms were compared applying Wilkoxon signed‐rank test and Lin's concordance coefficient. Kruskall‐Wallis test was used to compare the 4 groups on the basis of age, intra‐ocular pressure (IOP), perimetric indices as mean defect (MD) and pattern standard deviation (PSD),TSNIT,NFI,Q and TSS Results IOL group was significantly older, with lower IOP and higher MD as compared to the other groups. ECC gave better quality scans, thinner RNFL and higher NFI as compared to VCC. ECC/VCC outcomes were significantly different and concordance was poor to moderate but slightly better with transparent lens than with cataract (NO/NC3) or IOL. IOL and cataract seemed to affect GDx outcomes especially with VCC Conclusion different lens conditions seemed to influence laser polarimetry outcomes particularly with VCC. ECC as compared to VCC gave better quality scans, thinner RNFL, higher NFI and was less influenced by lens condition. ECC could possibly better reproduce RNFL thickness, giving a more reliable model of early glaucomatous neuropathy [ABSTRACT FROM AUTHOR]