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Considered in this paper is an inverse Robin problem governed by a steady-state diffusion equation. By the Robin inverse problem, one wants to recover the unknown Robin coefficient on an inaccessib...

Adsorption isotherms are the most important parameters in rigorous models of chromatographic processes. In this paper, in order to recover adsorption isotherms, we consider a coupled complex boundary method (CCBM), which was previously proposed for solving an inverse source problem [2]. With CCBM, the original boundary fitting problem is transferred to a domain fitting problem. Thus, this method has advantages regarding robustness and computation in reconstruction. In contrast to the traditional CCBM, for the sake of the reduction of computational complexity and computational cost, the recovered adsorption isotherm only corresponds to the real part of the solution of a forward complex initial boundary value problem. Furthermore, we take into account the position of the profiles and apply the momentum criterion to improve the optimization progress. Using Tikhonov regularization, the well-posedness, convergence properties and regularization parameter selection methods are studied. Based on an adjoint technique, we derive the exact Jacobian of the objective function and give an algorithm to reconstruct the adsorption isotherm. Finally, numerical simulations are given to show the feasibility and efficiency of the proposed regularization method.

Bioluminescence tomography (BLT) aims at the determination of the distribution of a bioluminescent source quantitatively. The mathematical problem involved is an inverse source problem and is ill-p...

We recently proposed in [Cheng, XL et al. A novel coupled complex boundary method for inverse source problems Inverse Problem 2014 30 055002] a coupled complex boundary method (CCBM) for inverse source problems. In this paper, we apply the CCBM to inverse conductivity problems (ICPs) with one measurement. In the ICP, the diffusion coefficient q is to be determined from both Dirichlet and Neumann boundary data. With the CCBM, q is sought such that the imaginary part of the solution of a forward Robin boundary value problem vanishes in the problem domain. This brings in advantages on robustness and computation in reconstruction. Based on the complex forward problem, the Tikhonov regularization is used for a stable reconstruction. Some theoretical analysis is given on the optimization models. Several numerical examples are provided to show the feasibility and usefulness of the CCBM for the ICP. It is illustrated that as long as all the subdomains share some portion of the boundary, our CCBM-based Tikhonov re...

We develop Second Order Asymptotical Regularization (SOAR) methods for solving inverse source problems in elliptic partial differential equations with both Dirichlet and Neumann boundary data. We show the convergence results of SOAR with the fixed damping parameter, as well as with a dynamic damping parameter, which is a continuous analog of Nesterov’s acceleration method. Moreover, by using Morozov’s discrepancy principle together with a newly developed total energy discrepancy principle, we prove that the approximate solution of SOAR weakly converges to an exact source function as the measurement noise goes to zero. A damped symplectic scheme, combined with the finite element method, is developed for the numerical implementation of SOAR, which yields a novel iterative regularization scheme for solving inverse source problems. Several numerical examples are given to show the accuracy and the acceleration effect of SOAR. A comparison with the state-of-the-art methods is also provided.

Bioluminescence tomography (BLT) is a new method in biomedical imaging, with a promising potential in monitoring non-invasively physiological and pathological processes in vivo at the cellular and molecular levels. The goal of BLT is to quantitatively reconstruct a three dimensional bioluminescent source distribution within a small animal from two dimensional optical signals on the surface of the animal body. Mathematically, BLT is an under-determined inverse source problem and is severely ill-posed, making its numerical treatments very challenging. In this paper, we provide a new Tikhonov regularization framework for the BLT problem. Compared with the existing reconstruction methods about BLT, our new method uses an energy functional defined over the whole problem domain for measuring the data fitting, associated with two related but different boundary value problems. Based on the new formulation, a fast solver is introduced by transforming the proposed optimization model into a system of partial differential equations. Moreover, a finite element method is used to obtain a regularized discrete solution. Finally, numerical results show that the fast solver for BLT is feasible and effective.

Biomedical imaging has developed into the level of molecular imaging. Bioluminescence tomography (BLT), as an optical imaging modality, is a rapidly developing new and promising field. So far, much of the theoretical analysis of BLT is based on a diffusion approximation equation for media with constant refractive index. In this article, we study the BLT problem for media with spatially varying refractive index. We introduce a general framework with Tikhonov regularization for this purpose, present its well-posedness and establish the error bounds for its numerical solution by the finite element method. Numerical results are reported on simulations of the BLT problem for media with spatially varying refractive index.

Bioluminescence tomography (BLT) is a promising new method in biomedical imaging. The BLT problem is an ill-posed inverse source problem, usually studied through a regularization technique. A new approach is proposed for solving the BLT problem based on an adjoint equation. Numerical examples show that the new formulation allows us to obtain accurate solutions.

Bioluminescence tomography (BLT) is a recently developed area in biomedical imaging. The goal of BLT is to quantitatively reconstruct a bioluminescent source distribution within a small animal from optical signals on the surface of the animal body. While there have been theoretical investigations of the BLT problem in the literature, in this paper, we propose a more general mathematical framework for a study of the BLT problem. For the proposed formulation, we establish a well-posedness result and explore its relation to the formulation studied previously in other papers. We introduce numerical methods for solving the BLT problem, show convergence, and derive error estimates for the discrete solutions. Numerical simulation results are presented showing improvement of solution accuracy with the new general mathematical framework over that with the standard formulation of BLT.