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BACKGROUND: Ischemic stroke is one of the main causes of death and long-term disability, and the incidence is still rising year by year, seriously affecting the quality of life. Blood-brain barrier injury is an important pathological process that leads to a poor prognosis of cerebral ischemia reperfusion injury. However, due to the limited treatment methods and limitations of multiple factors, it is urgent to find new treatment methods to repair blood-brain barrier injury. OBJECTIVE: To review the relevant mechanisms of traditional Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier after cerebral ischemia reperfusion injury, to further explore new ways to protect the blood-brain barrier and provide assistance for clinical treatment. METHODS: The keywords were “traditional Chinese medicine, bone marrow mesenchymal stem cells, blood-brain barrier, cerebral ischemia reperfusion injury” in Chinese and English. WanFang, CNKI, PubMed, and Web of Science databases from 2012 to 2022 were retrieved for articles regarding the related mechanism of the blood-brain barrier damage and the related mechanism of Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier. The obsolete and unqualified articles were excluded and 97 articles were included for analysis and summary. RESULTS AND CONCLUSION: (1) The physiological structure of the blood-brain barrier and the pathological changes of the blood-brain barrier structure after cerebral ischemia reperfusion injury were combed. (2) This paper summarized the mechanism of traditional Chinese medicine combined with bone marrow mesenchymal stem cells in regulating the blood-brain barrier after cerebral ischemia reperfusion injury, including regulating the expression of tight junction protein, inhibiting the activity of aquaporin-4 and matrix metalloproteinase-9, promoting angiogenesis, inhibiting the release of inflammatory mediators, and regulating exosomes. (3) It is concluded that traditional Chinese medicine combined with bone marrow mesenchymal stem cells can improve the permeability of the damaged blood-brain barrier and provide assistance for clinical treatment. [ABSTRACT FROM AUTHOR]

BACKGROUND: Rehmannia glutinosa has the effects of inhibiting oxidative stress, inhibiting apoptosis, inhibiting nerve inflammation, promoting angiogenesis and anti-aging, and has unique advantages in the treatment of ischemic stroke. The combination of Rehmannia glutinosa with mesenchymal stem cells as a carrier can play a better role in the treatment of ischemic stroke. OBJECTIVE: To review the research progress of Rehmannia glutinosa combined with mesenchymal stem cells in the treatment of ischemic stroke. METHODS: We searched CNKI and PubMed for the literature on the treatment of senile ischemic stroke with Rehmannia glutinosa combined with mesenchymal stem cells from 2012 to 2022. The keywords were “Rehmannia, mesenchymal stem cells (MSCs), ischemic stroke” in Chinese and English, respectively. Finally, 86 articles were included for further review. RESULTS AND CONCLUSION: (1) The mechanisms of mesenchymal stem cells in the treatment of ischemic stroke were reviewed, including the promotion of cell migration and differentiation, immunomodulation, and inhibition of apoptosis. (2) The mechanisms of Rehmannia glutinosa in treating ischemic stroke were summarized, including inhibition of oxidative stress, inhibition of nerve inflammation, inhibition of apoptosis, promotion of neuroangiogenesis, and anti-aging. (3) Rehmannia glutinosa could stimulate the vitality of mesenchymal stem cells, promote the proliferation of mesenchymal stem cells, induce the differentiation of mesenchymal stem cells into neuron-like cells, and improve the survival rate of mesenchymal stem cells in vivo, so as to achieve the goal of synergistic treatment of ischemic stroke. (4) The mechanism of Rehmannia glutinosa combined with mesenchymal stem cells in the treatment of ischemic stroke was summarized, including inhibition of oxidative stress, inhibition of apoptosis, anti-aging, promotion of angiogenesis and nerve remodeling, thereby providing theoretical reference for the new treatment of ischemic stroke in the future. [ABSTRACT FROM AUTHOR]