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Biodegradable microswimmers offer great potential for minimally invasive targeted therapy due to their tiny scale, multifunctionality, and versatility. However, most of the reported systems focused on the proof‐of‐concept on the in vitro level. Here, the successful fabrication of facile hydrogen‐powered microswimmers (HPMs) for precise and active therapy of acute ischemic stroke is demonstrated. The hydrogen (H2) generated locally from the designed magnesium (Mg) microswimmer functions not only as a propellant for motion, but also as an active ingredient for reactive oxygen species (ROS) and inflammation scavenging. Due to the continuous detachment of the produced H2, the motion of the microswimmers results in active H2 delivery that allows for enhanced extracellular and intracellular reducibility. With the help of a stereotaxic apparatus device, HPMs were injected precisely into the lateral ventricle of middle cerebral artery occlusion (MCAO) rats. By scavenging ROS and inflammation via active H2, MCAO rats exhibit significant decrease in infarct volume, improved spatial learning and memory capability with minimal adverse effects, demonstrating efficient efficacy on anti‐ischemic stroke. The as‐developed HPMs with excellent biocompatibility and ROS scavenging capability holds great promise for the treatment of acute ischemic stroke or other oxidative stress induced diseases in clinic in the near future. [ABSTRACT FROM AUTHOR]

Acute ischemic stroke, hydrogen-powered microswimmers, inflammation attenuating, minimally invasive therapy, ROS scavenging By scavenging ROS and inflammation via active hydrogen, the microswimmers exhibit an outstanding neuroprotection and ischemia stroke remedy effect, which also hold great promise for the treatment of other oxidative stress-induced diseases in clinical practice. Keywords: acute ischemic stroke; hydrogen-powered microswimmers; inflammation attenuating; minimally invasive therapy; ROS scavenging EN acute ischemic stroke hydrogen-powered microswimmers inflammation attenuating minimally invasive therapy ROS scavenging 1 1 1 05/12/21 20210510 NES 210510 In article number 2009475, Kun Liu, Shuwen Liu, Fei Peng, Yingfeng Tu, and co-workers present facile hydrogen-powered microswimmers for precise and active hydrogen therapy towards acute ischemic stroke. [Extracted from the article]