1. Leptin inhibition of insulin secretion from isolated human islets.
- Author
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Fehmann HC, Berghöfer P, Brandhorst D, Brandhorst H, Hering B, Bretzel RG, and Göke B
- Subjects
- Animals, Culture Techniques, Dose-Response Relationship, Drug, Humans, Insulin Secretion, Islets of Langerhans cytology, Islets of Langerhans drug effects, Islets of Langerhans pathology, Leptin, Mice, Glucose pharmacology, Insulin metabolism, Islets of Langerhans metabolism, Proteins pharmacology
- Abstract
Leptin is a hormone produced and secreted from the adipose tissue. Its physiological actions include the regulation of satiety, food intake and energy balance. The production of leptin is increased by high insulin levels. Here, we demonstrate that leptin acts as an inhibitor of glucose-induced (20 mM) insulin secretion from isolated human islets. No effect was observed in the presence of lower glucose levels (2.8 and 10 mM glucose). The pancreatic beta-cell might represent a target of a direct physiological action of leptin. We suggest the presence of an "adipo-insular axis" in which leptin mediates negative feedback from the adipose tissue to the endocrine pancreas.
- Published
- 1997
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