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The development of catalytic enantioselective isocyanide‐based reactions is currently of great interest because the resulting products are valuable in organic synthesis, pharmacological chemistry, and materials science. This review assembles and comprehensively summarizes the recent achievements in this rapidly growing area according to the reaction types. Special attention is paid to the advantages, limitations, possible mechanisms, and synthetic applications of each reaction. In addition, a personal outlook on the opportunities for further exploration is given at the end. [ABSTRACT FROM AUTHOR]

Keywords: [3+2] cycloaddition; cascade reactions; catalytic asymmetric; insertion reaction; isocyanide EN [3+2] cycloaddition cascade reactions catalytic asymmetric insertion reaction isocyanide 1 1 1 04/19/21 20210416 NES 210416 B The development of catalytic b enantioselective isocyanide-based reactions leading to products, which are valuable in organic synthesis, pharmacological chemistry, and materials science is currently of great interest. [3+2] cycloaddition, cascade reactions, catalytic asymmetric, insertion reaction, isocyanide Recent achievements in this rapidly growing area according to the reaction types, with special attention being paid to the advantages, limitations, possible mechanisms, and synthetic applications of each reaction is given in the Review by Y.-L. [Extracted from the article]

An expedient and economic approach for constructing O , O , N -spiro compounds consisting of both a 1,3-oxazine and a furan ring through a catalyst-free formal [4+1]/[4+2] cycloaddition cascade sequence of isocyanides with two molecules of acylketene formed in situ through thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones was developed. The reaction displayed good functional group tolerance and was compatible with different isocyanides and 2-diazo-1,3-diketones. Furthermore, preliminary asymmetric attempts of this reaction are made by utilizing optically pure isocyanides as inputs, and moderate diastereomeric induction was observed. [ABSTRACT FROM AUTHOR]