8 results on '"Grande, Enrico"'
Search Results
2. Suicide among adolescents in Italy: a nationwide cohort study of the role of family characteristics
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Grande, Enrico, Vichi, Monica, Alicandro, Gianfranco, Simeoni, Silvia, Murianni, Laura, Marchetti, Stefano, Zengarini, Nicolas, Frova, Luisa, and Pompili, Maurizio
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- 2021
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3. The increase of sepsis-related mortality in Italy: a nationwide study, 2003–2015
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Grande, Enrico, Grippo, Francesco, Frova, Luisa, Pantosti, Annalisa, Pezzotti, Patrizio, and Fedeli, Ugo
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- 2019
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4. Suicide mortality in Italy during the first year of the COVID-19 pandemic.
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Grande, Enrico, Grippo, Francesco, Crialesi, Roberta, Marchetti, Stefano, and Frova, Luisa
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PROOF & certification of death , *COVID-19 pandemic , *SUICIDE , *SUICIDE statistics , *AGE groups - Abstract
Italy was severely hit by COVID-19 during 2020 and great concern about the possible increase of suicide rates in the population has arisen since early pandemic phases. Analyses limited to March–April have shown a drop in suicides in both sexes. This study aims to analyze suicide mortality in Italy during the whole 2020 making comparisons with the pre-pandemic period 2015–19, by sex, age and geographic area. Official cause-of-death data with national coverage were used to analyze suicide mortality by sex, month, age class and geographic area in the population aged ≥10 years (54,595,179). The monthly number of suicide deaths in 2020 was compared to the average number in 2015–19. Age-specific and age-adjusted suicide rates in 2020 and in 2015–19 were compared using rate-ratios with 95 % confidence intervals. Compared to 2015–19 a non-significant reduction of the overall suicide rate was observed during 2020, both in males (−3 %) and females (−7 %). Suicide rates non-significantly decreased in most age groups; an increase, although not statistically significant, was found among males aged ≥75 years and females aged ≥85 years. Suicide deaths reduced mainly in Central-Southern areas and the Islands, while they slightly increased in the North especially among males. Study limitations include accuracy of death certification and the relatively brief observation period. The study contributes to the analysis of early effects of the COVID-19 pandemic on suicide mortality in the whole population highlighting sex, age and territorial differences and suggesting to monitor possible increases in a longer observation period. • In Italy, compared to 2015-19 a non-significant reduction of the overall suicide rate was observed in 2020, in both sexes • An increase in suicide rates, although non-significant, was found among males aged ≥75 years and females aged ≥85 years • The variation in the number of suicide deaths during 2020 is not uniform across the country [ABSTRACT FROM AUTHOR]
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- 2023
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5. Mortality Related to Chronic Obstructive Pulmonary Disease during the COVID-19 Pandemic: An Analysis of Multiple Causes of Death through Different Epidemic Waves in Veneto, Italy
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Fedeli, Ugo, Barbiellini Amidei, Claudio, Marcon, Alessandro, Casotto, Veronica, Grippo, Francesco, Grande, Enrico, Gaisl, Thomas, Barco, Stefano, University of Zurich, and Fedeli, Ugo
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Male ,Health, Toxicology and Mutagenesis ,10031 Clinic for Angiology ,Public Health, Environmental and Occupational Health ,COVID-19 ,610 Medicine & health ,2739 Public Health, Environmental and Occupational Health ,chronic obstructive pulmonary disease ,mortality ,multiple causes of death ,Pulmonary Disease, Chronic Obstructive ,Italy ,2310 Pollution ,Cause of Death ,2307 Health, Toxicology and Mutagenesis ,Humans ,Female ,10178 Clinic for Pneumology ,Mortality ,Pandemics - Abstract
Mortality related to chronic obstructive pulmonary disease (COPD) during the COVID-19 pandemic is possibly underestimated by sparse available data. The study aimed to assess the impact of the pandemic on COPD-related mortality by means of time series analyses of causes of death data. We analyzed the death certificates of residents in Veneto (Italy) aged ≥40 years from 2008 to 2020. The age-standardized rates were computed for COPD as the underlying cause of death (UCOD) and as any mention in death certificates (multiple cause of death—MCOD). The annual percent change (APC) in the rates was estimated for the pre-pandemic period. Excess COPD-related mortality in 2020 was estimated by means of Seasonal Autoregressive Integrated Moving Average models. Overall, COPD was mentioned in 7.2% (43,780) of all deaths. From 2008 to 2019, the APC for COPD-related mortality was −4.9% (95% CI −5.5%, −4.2%) in men and −3.1% in women (95% CI −3.8%, −2.5%). In 2020 compared to the 2018–2019 average, the number of deaths from COPD (UCOD) declined by 8%, while COPD-related deaths (MCOD) increased by 14% (95% CI 10–18%), with peaks corresponding to the COVID-19 epidemic waves. Time series analyses confirmed that in 2020, COPD-related mortality increased by 16%. Patients with COPD experienced significant excess mortality during the first year of the pandemic. The decline in COPD mortality as the UCOD is explained by COVID-19 acting as a competing cause, highlighting how an MCOD approach is needed.
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- 2022
6. Suicide mortality among the elderly population in Italy: A nationwide cohort study on gender differences in sociodemographic risk factors, method of suicide, and associated comorbidity.
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Grande, Enrico, Vichi, Monica, Alicandro, Gianfranco, Marchetti, Stefano, Frova, Luisa, and Pompili, Maurizio
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SUICIDE , *SEX distribution , *QUALITY of life , *COMORBIDITY , *LONGITUDINAL method - Abstract
Objectives: This study aimed at investigating gender differences in the relationship between sociodemographic factors and suicide mortality, as well as in the method used for suicide and the presence of comorbidities in an older population in Italy.Methods/design: We conducted a historical cohort study based on individual record linkage across the 15th Italian Population Census, the Italian Population Register, and the National Register of Causes of Death. Suicides among people aged 75 years or older from 2012 to 2017 were analyzed. Crude mortality rates were computed, and cause-specific mortality rate ratios were estimated using negative binomial regression models. Chi-square tests were used to evaluate significant gender differences in suicide methods and comorbidities associated with suicide.Results: The study included 9,686,698 individuals (41% men, 59% women). Compared to living alone, living with children or partners reduced suicide mortality, especially among men. Having high or medium educational levels was associated with lower mortality than low educational levels among men. Foreign citizens had lower mortality among men, but not among women. Living in urban areas was associated with lower suicide rates in men and higher rates in women. Methods of suicide significantly differed by gender: leading methods were hanging, strangulation, and suffocation in men, and falling from height in women. Mental comorbidity was significantly more frequent among women, especially at ages 75-84 years.Conclusions: We believe that our findings might help to promote public health strategies taking gender differences in old age into account to improve social support and quality of life of older men and women. [ABSTRACT FROM AUTHOR]- Published
- 2022
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7. Multiple cause-of-death data among people with AIDS in Italy: a nationwide cross-sectional study.
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Grande, Enrico, Zucchetto, Antonella, Suligoi, Barbara, Grippo, Francesco, Pappagallo, Marilena, Virdone, Saverio, Camoni, Laura, Taborelli, Martina, Regine, Vincenza, Serraino, Diego, and Frova, Luisa
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MORTALITY of AIDS patients , *AIDS , *CONFIDENCE intervals , *CAUSES of death , *NOSOLOGY , *RESEARCH funding , *DEATH certificates , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Background: Multiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on the death certificate that are not selected as the underlying cause of death. Using MCOD data, this study aimed to fully describe the cause-specific mortality of people with AIDS (PWA) compared to people without AIDS. Methods: We conducted a nationwide investigation based on death certificates of 2,515 Italian PWA and 123,224 people without AIDS who had died between 2006 and 2010. The conditions most frequently associated with PWA mortality, compared to people without AIDS, were identified using an age-standardized proportion ratio (ASPR) calculated as the ratio between the age-standardized proportion of a specific cause among PWA and the same proportion among people without AIDS. Results: The most frequently reported conditions at death among PWA were infectious/parasitic diseases (52%), digestive (36%), respiratory (33%), and circulatory (32%) system diseases, and neoplasms (29%). All AIDS-defining conditions resulted highly associated (ASPR significantly greater than unity) with PWA deaths. Significant associations also emerged for leishmaniasis (ASPR = 188.0), encephalitis/myelitis/encephalomyelitis (ASPR = 14.3), dementia (ASPR = 13.1), chronic viral hepatitis (ASPR = 13.1), liver fibrosis/cirrhosis (ASPR = 4.4), pneumonia (ASPR = 4.4), anal (ASPR = 12.1) and liver (ASPR = 1.9) cancers, and Hodgkin's disease (ASPR = 3.1). Conclusions: Study findings identified the contribution of several non-AIDS-defining conditions on PWA mortality, emphasizing the need of preventive public health interventions targeting this population. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Risk factors for early mortality after AIDS in the cART era: A population-based cohort study in Italy.
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Suligoi, Barbara, Zucchetto, Antonella, Grande, Enrico, Camoni, Laura, Maso, Luigino Dal, Frova, Luisa, Virdone, Saverio, Boros, Stefano, Pappagallo, Marilena, Taborelli, Martina, Regine, Vincenza, De Paoli, Paolo, and Serraino, Diego
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AIDS patients ,MORTALITY of AIDS patients ,HIV infection prognosis ,KAPLAN-Meier estimator ,CONFIDENCE intervals ,LOGISTIC regression analysis - Abstract
Background: Despite the dramatically improved survival due to combination antiretroviral therapies (cART), life expectancy of people with HIV/AIDS remains lower than that of the general population. This study aimed to estimate, at a population level, the survival experience of Italian people with AIDS (PWA) and to quantify the prognostic role of selected factors at diagnosis in the risk of early mortality (i.e., within six months from AIDS diagnosis). Methods: A population-based, retrospective-cohort study was conducted among Italian PWA diagnosed between 1999 and 2009 and recorded in the national AIDS registry. The vital status, up to December 2010, of 14,552 PWA was ascertained through a record linkage procedure with the Italian mortality database. Survival probabilities were estimated through Kaplan-Meier method. To identify risk factors for early mortality from any cause, odds ratios (ORs) and corresponding 95 % confidence intervals (CIs), adjusted for major confounders, were computed using multivariate logistic regression models. Results: Of the 5,706 deaths registered among the 14,552 PWA included in the study, 2,757 (18.9 %) occurred within six months from AIDS diagnosis. The probability of surviving six months increased from 81.2 % in PWA diagnosed in 1999-2000 to 82.9 % in 2009, while the 5-year survival augmented from 60.7 % in PWA diagnosed in 1999-2000 to 65.4 % for PWA diagnosed in 2005-2006. Elevated risks of early mortality were associated to older age (OR = 5.28; 95 % CI: 4.41-6.32 for age ≥60 vs. <35 years), injecting drug use (OR = 1.71; 95 % CI: 1.53-1.91 vs. heterosexual intercourse), and CD4 count <50 cells/mm³ at AIDS diagnosis (OR = 1.87, 95 % CI: 1.55-2.27 vs. ≥350). Elevated ORs for early mortality also emerged for PWA diagnosed with primary brain lymphoma (OR= 11.66, 95 % CI: 7.32-18.57), or progressive multifocal leukoencephalopathy (OR = 4.21, 95 % CI: 3.37-5.27). Conclusions: Our study documented, among Italian PWA, the high -- though slightly decreasing - frequency of early mortality in the full cART era. These findings indicate the need for enduring and ameliorating preventive actions aimed at timely HIV testing among all individuals at risk for HIV infection and/or those who present diseases known to be related with HIV infection. [ABSTRACT FROM AUTHOR]
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- 2015
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