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Introduction: Ocular Pulse Amplitude (OPA) is the fluctuation of IOP with the cardiac cycle which is equal to the difference between systolic and diastolic IOP. These variations in IOP are thought to be caused by the blood volume that is pumped into the eye, mainly the choroidal bed during each cardiac cycle. In patients with end stage renal disease (ESRD), Choroidal perfusion has been found to be reduced as determined by Indocyanine Green Angiography (ICG) which is an invasive procedure. OPA is recorded by Dynamic Contour Tonometer (DCT) which represents a potential new technology for measuring choroidal blood flow indirectly & non-invasively especially in patients with suspected compromise in perfusion as in ESRD. In this study we postulate that measurement of OPA can be used to assess the choroidal perfusion inpatients with ESRD., Objectives: To measure OPA in non-diabetic patients with ESRD on hemodialysis and to compare it with that of OPA in age matched normal individuals., Materials & Methods: It was a prospective Cross-sectional study and was done in a clinical set up during the period of January 2013 to October 2013. OPA among 44exposed and 44 non exposed individuals were measured using Dynamic Contour Tonometry (DCT) and analysis done., Results: The mean OPA in non diabetic patients with ESRD was 1.945mm Hg (CI:1.847 - 2.043) and the mean OPA in age matched normals was 2.16mm Hg (CI: 2.08- 2.24)., Conclusion: OPA in non diabetic ESRD patients was statistically significantly lower than that of age matched normals (p=0.03). There was no correlation between OPA and other parameters like age, gender, intraocular pressure, blood pressure or serumcreatinine levels., (© NEPjOPH.)

♦ BACKGROUND: There are no large studies that have examined ultra-short break-in period with a blind, bedside, midline approach to Tenckhoff catheter insertion. ♦ METHODS: Observational cohort study of 245 consecutive adult patients who underwent percutaneous catheter insertion for chronic peritoneal dialysis (PD) at our center from January 2009 to December 2013. There were 132 (53.9%) diabetics and 113 (46.1%) non-diabetics in the cohort. ♦ RESULTS: The mean break-in period for the percutaneous group was 2.68 ± 2.6 days. There were significantly more males among the diabetics (103 [78%] vs 66 [58.4%], p = 0.001). Diabetics had a significantly higher body mass index (BMI) (23.9 ± 3.7 kg/m 2 vs 22.2 ± 4 kg/m 2 , p < 0.001) and lower serum albumin (33.1 ± 6.3 g/L vs 37 ± 6 g/L, p < 0.001) compared with non-diabetics. Poor catheter outflow was present in 6 (4.5%) diabetics and 16 (14.2%) non-diabetics (p = 0.009). Catheter migration was also significantly more common in the non-diabetic group (11 [9.7%] vs 2 [1.5%], p = 0.004). Primary catheter non-function was present in 17(15%) of the non-diabetics and in 7(5.3%) of the diabetics (p = 0.01). There were no mortality or major non-procedural complications during the catheter insertions. Among patients with 1 year of follow-up data, catheter survival (93/102 [91.2%] vs 71/82 [86.6%], p = 0.32) and technique survival (93/102 [91.2%] vs 70/82 [85.4%], p = 0.22) at 1 year was comparable between diabetics and non-diabetics, respectively. ♦ CONCLUSIONS: Percutaneous catheter insertion by practicing nephrologists provides a short break-in period with very low mechanical and infective complications. Non-diabetic status emerged as a significant risk factor for primary catheter non-function presumed to be due to more patients with lower BMI and thus smaller abdominal cavities. This is the first report that systematically compares diabetic and non-diabetic patients., (Copyright © 2016 International Society for Peritoneal Dialysis.)