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Objective: To Compare the Diagnostic Accuracy of the Colour Doppler twinkling artefact with Computed Tomography of the Kidney, ureters, and bladder in the detection of Nephrolithiasis - Point of Care Ultrasonography. Study Design: Comparative prospective study. Place and Duration of Study: Department of Diagnostic Radiology, Combined Military Hospital, Pakistan, from Jan 2023 to Apr 2023. Methodology: A total of 370 patients referred from hospital emergency for evaluation of renal colic of the age group 18-65 years were evaluated. Greyscale ultrasound and Colour Doppler TA were performed at the emergency department as a point-of-care ultrasonography. All patients were subsequently referred for Computed Tomography of the Kidney, ureters. Results: Diagnostic yield of Colours Doppler TA was comparable to CT KUB and slightly greater GSU. The sensitivity, Specificity, Positive predictive value, Negative predictive value and Accuracy for TA and GSU was 99.33%, 92.01%, 96.92%, 83.64%,92.97% and 89.63%, 88.0%, 95.28%,75.86% 89.19% respectively. The mean time required for GSU / Colour Doppler TA diagnosis was 39.32 ± 9.36 Minutes and 27.87 ± 15.45 hours for CT KUB. Conclusion: The diagnostic yield of colour Doppler twinkling artefact is comparable to Computed Tomography of the kidney, ureters, and bladder in diagnosing acute renal colic. It is a reliable alternative to GSU and CT-KUB in emergency setups as a point-of-care ultrasonography. [ABSTRACT FROM AUTHOR]