1. Rapid reversal of uremic neuropathy following renal transplantation in an adolescent.
- Author
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Ho DT, Rodig NM, Kim HB, Lidov HG, Shapiro FD, Raju GP, and Kang PB
- Subjects
- Adolescent, Axons pathology, Biopsy methods, Female, Humans, Neural Conduction, Polyneuropathies etiology, Sural Nerve pathology, Treatment Outcome, Glomerulosclerosis, Focal Segmental therapy, Kidney Transplantation methods, Polyneuropathies therapy, Renal Insufficiency therapy, Uremia therapy
- Abstract
Clinical and pathologic studies on adults with uremic neuropathy are numerous, but less is known about this disorder in children and adolescents. We report the clinical, electrophysiologic, and pathologic findings in an adolescent female with uremic neuropathy. Electrophysiologic findings were consistent with a primarily axonal sensorimotor polyneuropathy. Sural nerve biopsy revealed areas of focal depletion in myelin sheaths and loss of axons. Axonal degeneration with secondary myelin changes appears to be the characteristic pathology in this case, one of the youngest to our knowledge for which nerve biopsy data are available. Our patient experienced dramatic recovery after renal transplantation, similar to the reports of older patients., (© 2011 John Wiley & Sons A/S.)
- Published
- 2012
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