1. A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae .
- Author
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Yasmin M, Marshall SH, Chen L, Rhoads DD, Jacobs MR, Rojas LJ, Perez F, Hujer AM, Hujer KM, van Duin D, Fowler V, Chambers HF, Kreiswirth BN, and Bonomo RA
- Subjects
- Porins genetics, Porins metabolism, Humans, Mutation, Klebsiella Infections microbiology, Klebsiella Infections drug therapy, Drug Combinations, Drug Resistance, Multiple, Bacterial genetics, Heterocyclic Compounds, 1-Ring, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae genetics, Meropenem pharmacology, Microbial Sensitivity Tests, beta-Lactamases genetics, beta-Lactamases metabolism, Anti-Bacterial Agents pharmacology, Boronic Acids pharmacology, Bacterial Proteins genetics, Bacterial Proteins metabolism, Whole Genome Sequencing
- Abstract
We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-β-lactamase-producing KPC- Klebsiella pneumoniae (KPC- KP ). Whole-genome sequencing was performed to identify mutations associated with MV non-susceptibility. Isolates with elevated MV MICs were found to have mutations encoding truncated or altered OmpK36 porins and increased bla
KPC copy numbers. KPC- KP isolates with decreased susceptibility to MV were detected among a collection of isolates predating the availability of MV., Competing Interests: The authors declare no conflict of interest.- Published
- 2024
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