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Background: Biomechanical changes in articular cartilage are associated with the onset of osteoarthritis. We developed an optical coherence tomography-based strain rate tomography method: stress relaxation optical coherence straingraphy (SR-OCSA). The purpose of this study was to establish an approach for measuring mechanical properties of articular cartilage using SR-OCSA, and to investigate the distribution of viscoelastic properties of articular cartilage in early osteoarthritis., Methods: Anterior cruciate ligament transection surgery was performed on the left knees of 8-9-month-old New Zealand white rabbits. SR-OCSA was used to visualize and measure the viscoelastic properties of articular cartilage via attenuation coefficient of strain rate (ACSR). Using the same conditions as in the SR-OCSA test, an indentation test was conducted, and relaxation time was measured to evaluate the relationship between ACSR and relaxation time., Results: SR-OCSA could nondestructively detect and visualize changes in the distribution of viscoelastic properties of articular cartilage in early osteoarthritis. SR-OCSA captured significant increases in ACSR in cartilage at 2 weeks after surgery, when a histologically slight osteoarthritis sign was present. As cartilage degeneration progressed, ACSR increased, whereas relaxation time decreased in a time-dependent manner. Moreover, ACSR negatively correlated with relaxation time. In particular, ACSR was elevated around the tidemark and the elevation tended to move as cartilage degeneration progressed., Conclusions: SR-OCSA could tomographically and nondestructively detect and visualize changes in the distribution of viscoelastic properties of articular cartilage in early osteoarthritis. The mechanical properties around the tidemark were degraded as cartilage degeneration progressed. Thus, SR-OCSA provides important data needed to understand the biomechanics of early osteoarthritis.

Background: Patella-post impingement (PPI), contact of the patellar component with the tibial post, occurs during deep knee flexion after posterior stabilized total knee arthroplasty (TKA). In a previous pilot study, only two product lines were investigated. The aim of this study was to compare PPI between 12 contemporary posterior stabilized knee prostheses., Methods: Twelve posterior stabilized knee prostheses were implanted in full-length sawbone models of the femur and tibia using a navigation system. The distance between the lower edge of the patellar component and the cut surface of the tibia was defined as the tibial-patellar clearance (TPC), which represents the length of the patellar tendon. The TPC was set from 20 to 40 mm and the knee was moved from full extension to deep flexion while the knee angle at which PPI occurred (PPI angle) was recorded., Results: The PPI angle differed between prostheses (P < 0.05). Shorter TPCs resulted in smaller PPI angles and longer TPCs resulted in larger PPI angles (P < 0.05). To achieve more than 130° of flexion without PPI, the TPC should be prepared at a minimum of 20 mm for the NexGen LPS-Flex, Persona PS, Legion PS, and Evolution PS, 22 mm for the Attune RP and Journey II, 24 mm for the Triathlon PS, PFC Sigma PS, and Attune PS, and 26 mm for the NRG PS, Vanguard PS, and Vanguard RP., Conclusions: The design of the tibial post significantly affects the PPI angle. To avoid PPI during deep flexion, appropriate TPC should be prepared during surgery., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Introduction: Proper anteroposterior (AP) joint displacement is an important indicator of good clinical outcome following total knee arthroplasty (TKA). We hypothesized that a newly introduced mobile-bearing posterior stabilized (PS) prosthesis reduces the AP joint displacement. The aim of this study is to compare the AP joint displacement between a newly introduced mobile-bearing PS TKA in one knee and a conventional fixed-bearing PS TKA in other knee., Materials and Methods: 82 knees in 41 patients who had bilateral TKAs were investigated. All the patients received a conventional fixed-bearing PS prosthesis in one knee and a highly congruent mobile-bearing PS prosthesis in the other knee. AP joint displacement was measured using the KT-2000 arthrometer, at 30° and 75° in flexion, at average of 3.3 years after the operation., Results: AP joint displacements at 30° in flexion were 6 ± 3 mm in the knees with the mobile-bearing PS prosthesis and 9 ± 4 mm in the knee with fixed-bearing PS prosthesis (p < 0.001). AP joint displacements at 75° in flexion were 4 ± 2 mm in the knees with the mobile-bearing PS prosthesis and 6 ± 3 mm in the knee with fixed-bearing PS prosthesis (p < 0.001)., Conclusions: This study suggested that the design of the prosthesis can improve the AP joint stability in mid-flexion range.

Purpose: Posterior reference guides are provided by many manufacturers. However, the true posterior femoral condyle bone resection thicknesses using posterior reference guides are not stated by the manufacturers. The purpose of this study was to analyse the influence of the posterior reference guide designs on the posterior femoral condyle bone resection thickness., Methods: Thickness of posterior femoral condyle bone resection and thickness of prostheses were investigated in 8 types of total knee prostheses using the production drawings provided by the manufacturers., Results: Posterior femoral condyle bone resection thickness differed between prostheses. Change in size of the medial posterior condyle ranged from -0.5 to 1.4 mm at 0° external rotation, from -2.9 to 1.4 mm at 3° external rotation, and from -5.3 to 1.4 mm at 6° external rotation. Change in size of lateral posterior condyle ranged from -0.5 to 1.4 mm at 0° external rotation, from -0.4 to 3.4 mm at 3° external rotation, and from -0.4 to 5.3 mm at 6° external rotation., Conclusions: This study showed that posterior femoral condyle bone resection thickness was different for each posterior reference guide. The rotation centre of posterior reference guides influenced the bone resection thickness in the posterior femoral condyle. The size of the posterior femoral condyles increased in some guides but decreased in other guides. The maximum differences in size changes of the posterior femoral condyles between the guides were 1.9 mm at 0° external rotation, 4.1 mm at 3° external rotation, and 6.3 mm at 6° external rotation. To control the size of posterior femoral condyles, the posterior reference guide design should be checked before use.

Purpose: Range of motion is a crucial measure of the outcome of total knee arthroplasty. Gap balancing technique and mobile-bearing prosthesis can improve postoperative range of motion. The purpose of this study was to determine the factors that are predictive of the postoperative range of motion., Methods: A total of 94 knees with varus osteoarthritis were prospectively randomized to receive either a posterior-stabilized mobile-bearing or a posterior-stabilized fixed-bearing prosthesis. All preoperative and postoperative protocols and operative techniques were identical in the two groups. Extension and flexion joint gaps were measured using a tensor device during the operation. Multiple regression analysis was conducted to determine the best predictors of the knee flexion angle 2 years after the operation. The independent variables were type of prosthesis (mobile-bearing or fixed-bearing), difference between flexion and extension joint gaps (mm), age, gender, body mass index (BMI), preoperative and intraoperative knee flexion angles, change in posterior condylar offset, and posterior tilt of the tibial plateau., Results: The mean difference between flexion and extension joint gaps was 0.8 ± 1.3 (mean ± SD) mm for mobile-bearing and 0.8 ± 1.9 mm for fixed-bearing prosthesis. The mean flexion angle for mobile-bearing and fixed-bearing groups was 120 ± 16° and 116 ± 20° preoperatively (n.s.), 142 ± 9° and 141 ± 12° intraoperatively (n.s.), and 129 ± 10° and 128 ± 13° at 2 years postoperatively (p = 0.773), respectively. Predictors were identified in the following three categories: (1) preoperative flexion angle, (2) intraoperative radiographic flexion angle, and (3) BMI (R = 0.603, p < 0.001)., Conclusions: Mobile-bearing prosthesis and optimal gap balancing did not result in superior postoperative flexion angle. Better preoperative and intraoperative flexion angles and lower BMI were the significant predictors for better postoperative flexion angle., Level of Evidence: Therapeutic study, Level I.

Large bone defect around total knee prostheses is among the most critical challenges in revision surgery. However, it is difficult to detect bone defects around a prosthesis in early stage. We compared the efficacy of the detection of small bone defects between fluoroscopically guided plain radiography, CT, MRI, and a novel tomographic technique (tomosynthesis) using the six pig knee models. No bone defects were detected with plain radiography and MRI. The sensitivity and specificity of CT were 61.5% and 64.1%, respectively. The sensitivity and specificity of tomosynthesis were 85.4% and 87.2%, respectively. The radiation dose of tomosynthesis was 6% of that of CT. The cost of tomosynthesis was 28% of that of CT. Tomosynthesis was superior in terms of diagnosis, radiation dose, and cost., (Copyright © 2014 Elsevier Inc. All rights reserved.)

Purpose: Navigation systems have recently been developed to achieve highly reliable prosthetic alignment in total knee arthroplasty (TKA). However, component alignment in the sagittal plane is less reliable than that in the coronal plane even when navigation systems are used. Previous reports examining men showed differences in targeted sagittal prosthetic alignments of TKA achieved using the conventional technique and various navigation systems. However, there have been few studies examining the use of this technique in women, who are the primary candidates for TKA., Methods: Radiographs of the entire lower extremity were obtained from 20 elder women while standing and sagittal prosthetic alignments in TKA were planned using the conventional technique as well as three navigation approaches to establish reference frames, and the observations were compared., Results: Sagittal alignments simulated using the radiographs for the conventional technique and navigation systems differed within a mean of 3.2° ± 1.7° (mean ± SD) to 6.3° ± 2.0°. The use of different reference points on the distal femoral condyles (insertion point of the intramedullary rod, center of the anteroposterior direction of the femoral condyles, and most distal point of the femoral condyles) for each navigation system resulted in differences in the sagittal plane up to 3.0° ± 1.5°. The use of navigation systems resulted in a more hyperextended position between the femoral and tibial components compared to that for the conventional technique., Conclusions: Targeted sagittal prosthetic alignments of TKA achieved using the conventional technique and various navigation systems differed in elderly women. The use of different reference points on the distal femoral condyle for navigation systems resulted in different alignment in the sagittal plane. This study showed that alignment tendencies are similar in men and women., Level of Evidence: Prognostic studies, IV.

Purpose: The medial pivot total knee prosthesis has been designed to reproduce physiological knee kinematics. It has been reported that alumina ceramic femoral components reduce polyethylene wear. Thus, medial pivot total knee prostheses with alumina ceramic femoral components were introduced. The purpose of this study was to evaluate the clinical results of patients who underwent newly introduced alumina medial pivot total knee arthroplasties (TKA)., Methods: We evaluated the clinical results of 107 alumina medial pivot TKAs in 80 consecutive patients with a mean follow-up period of 5 years., Results: Alumina medial pivot TKAs provided significant improvements in the patients' Knee Society knee scores, function scores and post-operative ranges of motion compared with their pre-operative statuses (each, P < 0.05). There was no statistical correlation between the change in maximum knee flexion and the increase in posterior condylar offset. Revision surgery was required in one knee due to a post-operative fracture of the tibial plateau after a fall that occurred 2 years postoperatively. No knees had aseptic loosening, osteolysis, or ceramic fractures. The survival rate was 98.6% at 5 years., Conclusions: This study demonstrates satisfactory mid-term clinical results for patients receiving the alumina medial pivot prosthesis., Level of Evidence: Therapeutic study, Level IV.