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Start Over Author "Cheng, Shidan" Topic kras
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2. The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models.

Author

Shen, Ruizhe, Wang, Qi, Cheng, Shidan, Liu, Tingting, Jiang, He, Zhu, Jiaxing, Wu, Yunlin, and Wang, Lifu

Subjects
*RAS oncogenes, *GENETIC mutation, *TRANSGENIC organisms, *LABORATORY mice, *PANCREATIC cancer, *PHOSPHOPROTEIN phosphatases, EPITHELIAL cell tumors
Abstract

Highlights: [•] Based on genetically engineered mouse, we analyzed the biological features of PanIN. [•] PanIN showed tumorigenic ability, but did not undergo a malignant transformation. [•] We first found the differential expression of PPP2R2A between PanIN and PDAC. [•] PPP2R2A expression is significantly higher in PanIN tissues than PDAC tissues. [•] The expression of PPP2R2A appears to be correlated with clinical survival. [Copyright &y& Elsevier]

Published
2013
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