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In this paper, we present a statistical approach to evaluate the relationship between variables observed in a two-factors experiment. We consider a three-level model with covariance structure Σ ⊗ Ψ 1 ⊗ Ψ 2 , where Σ is an arbitrary positive definite covariance matrix, and Ψ 1 and Ψ 2 are both correlation matrices with a compound symmetric structure corresponding to two different factors. The Rao's score test is used to test the hypotheses that observations grouped by one or two factors are uncorrelated. We analyze a fermentation process to illustrate the results. Supplementary materials accompanying this paper appear online. [ABSTRACT FROM AUTHOR]

In this paper we present properties of an algorithm to determine the maximum likelihood estimators of the covariance matrix when two processes jointly affect the observations. Additionally, one process is partially modeled by a compound symmetry structure. We perform a simulation study of the properties of an iteratively determined estimator of the covariance matrix. [ABSTRACT FROM AUTHOR]