1. Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model.
- Author
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Van Belle, Tom L., Esplugues, Enric, Liao, Jeanette, Juntti, Therese, Flavell, Richard A., and von Herrath, Matthias G.
- Subjects
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DIAGNOSIS of diabetes , *AUTOIMMUNE disease diagnosis , *GREEN fluorescent protein , *LABORATORY mice , *KLEBSIELLA pneumoniae , *LYMPHOCYTIC choriomeningitis virus , *THERAPEUTICS - Abstract
Recent studies have shown that IL-17 can contribute beneficially to pathogen defense but also that excessive IL-17 levels are associated with chronic inflammation and autoimmune disorders. To date, the role of IL-17 in viral infections and type 1 diabetes is ambiguous. In this study, we used IL-17A enhanced green fluorescent protein bicistronic reporter mouse strains to analyze in situ production of IL-17A. Upon Klebsiella pneumoniae bacterial infection, CD4+ and γδ T cells produce IL-17A. In contrast, CD4+ or CD8+ T cells do not produce IL-17A in response to acute or protracted viral infection with lymphocytic choriomeningitis virus or during autoimmune diabetes development in the CD8-driven lymphocytic choriomeningitis virus-induced model of type 1 diabetes. We conclude that viral elimination and type 1 diabetes can occur in the absence of detectable IL-17A production, suggesting IL-17A is not essential in these settings. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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