1. Platycodin D Exerts Anticancer Effects by Promoting Mitochondrial Apoptosis in Laryngeal Squamous Cell Carcinoma.
- Author
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Meihua Kong, Yanzhi Cai, and Qian He
- Subjects
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SQUAMOUS cell carcinoma , *MITOCHONDRIA , *CARRIER proteins , *ANTINEOPLASTIC agents , *APOPTOSIS , *CELL proliferation , *PLANT roots , *LARYNX , *TREATMENT effectiveness , *PLANT extracts , *CELL culture , *GENE expression , *MEDICINAL plants , *MOLECULAR structure ,LARYNGEAL tumors - Abstract
Laryngeal squamous cell carcinoma is a challenging malignancy with increasing incidence globally, necessitating the exploration of novel therapeutic strategies. Platycodin D, a saponin derived from Platycodon grandiflorum, has shown promise in cancer therapy, exhibiting anticancer effects in various tumor types. However, the specific mechanisms of action of Platycodin D in laryngeal squamous cell carcinoma remain poorly understood. Therefore, our study aimed to investigate the anticancer effects of Platycodin D in laryngeal squamous cell carcinoma. We revealed that Platycodin D effectively inhibited the proliferation of laryngeal squamous cell carcinoma cells and induced mitochondrial apoptosis. Furthermore, we found that Platycodin D downregulated the expression of S-phase kinase-associated protein 2, indicating a novel target for PD's action. Finally, the suppression of S-phase kinase-associated protein 2 by Platycodin D led to cell cycle arrest and enhanced apoptosis in laryngeal squamous cell carcinoma cells. Collectively, these findings underscore the potential of Platycodin D as a novel therapeutic agent for laryngeal squamous cell carcinoma, with implications for targeting mitochondrial apoptosis and S-phase kinase-associated protein 2 in cancer treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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