Search

The aim of this study was to compare the efficacy and adverse effects of a 595-nm pulsed dye laser therapy alone (PDL alone) with a 5-aminolevulinic (5-ALA) local application followed by a 595-nm PDL (5-ALA PDL) in the treatment of superficial hemangioma (SH). A prospectively randomized study in 181 patients with SH was carried out over a period of 24 months. One hundred and ninety-three patients were seen. One hundred and eighty-one patients with SH were enrolled, of which 165 completed final follow-up. One hundred and nineteen patients received PDL alone and 46 received 5-ALA PDL. The patients were assessed clinically and the patient's parents were given a satisfaction questionnaire. Baseline patient data (gender, lesion size, lesion site, treatment times, cure rate, and adverse reactions) were recorded and the results of the treatment of the two groups were analyzed and compared. Complete clearing of the lesion (recovery grade 4) was achieved in 44/119 (37.0%) of the PDL alone group and 31/46 (67.4%) of the 5-ALA PDL group (X 2  = 10.30, p < 0.001). Atrophic scars, hyper- and hypopigmentation occurred in both groups (X 2  = 3.32, p = 0.564). The patients' parents' satisfaction was greater in the 5-ALA PDL group. The clinical outcome of 5-ALA PDL was superior to that of PDL alone in the treatment of SH and only minor adverse events occurred in each group.

Unlabelled: Abstract Background: The 595 nm tunable pulsed dye laser has been used in China for more than 10 years. However, no studies about its effect and side-effect in treatment of superficial hemangioma have been documented., Objective: This study was designed to retrospectively summarize its usage in Chinese patients., Methods: Infant patients with superficial hemangioma, who had received 595 nm tunable pulsed dye laser treatment in our laser center in the last 10 years, were recruited. Detailed demographics, results of assessment about their degree of clearance and clinical examination for treatment complications were entered into SASS10.0 version database, and statistical analyses were conducted., Results: Six hundred and fifty-seven cases with superficial hemangioma were recruited. The overall effectiveness rate was 91.17%. Female patients respond better than male, the difference was statistically significant (p<0.001). Lesions at different part of the body respond differently to the treatment with lesions on extremities show the best result. The response rate does not increase with time of treatments. The most common side-effects were pigment changes and skin atrophy, which usually resolve spontaneously and disappear completely in a few months., Conclusions: Our experience confirmed the satisfactory clinical efficacy and safety of the 595 nm tunable pulse dye laser in the treatment of childhood superficial hemangioma.

Objective: Pulsed dye laser has been proved to be fairly effective in the treatment of infantile hemangioma. But the effect varies in different body sites. The objective of this study was to assess the long-term outcome and complications of 595 nm pulsed dye laser in the treatment of hand infantile hemangioma in our laser department, retrospectively., Patients and Methods: The patients with hand infantile hemangioma who had received pulsed dye laser (595 nm V-beam, Candela Cop., Wayland, MA., Parameters: fluence 10∼13 J/cm2, pulse duration 20∼40 ms, spot diameter 7 mm, epidermal cooling 20/40 s) treatment in past 5 years were recruited for the study. Detailed demographics, results of questionnaires and clinical examination were entered into a database and statistical analyses were conducted where applicable., Results: 43 patients with hand infantile hemangioma were recruited, including 29 females and 14 males, with a mean age of 8.92 months at treatment time. 7 patients with 10 hemangioma lesions at other sites from the hand meanwhile received laser treatment. There was a significant difference in the subjective assessment of clearing between hand lesions and additional other site hemangioma (p<0.001). The average Patient Satisfaction Score was 7.25 for hand hemangioma, the average Patient Satisfaction Score was 4.45 for other site hemangioma lesions, there was a significant difference between hand and non-hand lesions (p<0.001)., Conclusions: 595 nm pulsed dye laser provides a safe and effective modality with lower morbidity for hand hemangioma.

Objective: To evaluate the effectiveness and safety of topical application of 5-aminolevulinic acid (ALA) followed by pulsed dye laser (PDL) irradiation for the treatment of recalcitrant port-wine stain (PWS)., Methods: Thirty-five patients (19 females and 16 males) with recalcitrant PWS were treated with topical application of 20% ALA and then irradiated with a 595-nm PDL (energy density of 6.5-9.0 J/cm(2) and pulse duration of 6 or 10 ms) at 6-8 weeks intervals. Clinical improvement of lesions was evaluated by comparing photographs of lesions at baseline and 2 months after the last treatment., Results: Topical ALA spreading followed by irradiation with a 595-nm PDL improved PWS in 21 out of 35 patients who were previously recalcitrant to PDL treatment alone. Side effects were limited to transient erythema, vesicle formation, edema and mild purpura with no obvious subsequent scarring or undesirable pigment changes., Conclusion: The topical application of ALA followed by irradiation with a 595-nm PDL is an effective and safe treatment for PWS recalcitrant to PDL therapy alone.