1. Multitarget Transcranial Ultrasound Therapy in Small Animals Based on Phase-Only Acoustic Holographic Lens
- Author
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Maodan Yuan, Lvming Zeng, Yan Chen, Junwei Wu, Yiyue Zhu, Xuanrong Ji, and He Jiaru
- Subjects
Materials science ,Acoustics and Ultrasonics ,Phased array ,Ultrasonic Therapy ,Transducers ,Holography ,Acoustics ,Acoustic holography ,Rats ,law.invention ,Transcranial Doppler ,Lens (optics) ,Full width at half maximum ,law ,Animals ,Humans ,Focal length ,Electrical and Electronic Engineering ,Instrumentation ,Image resolution ,Ultrasonography ,Biomedical engineering - Abstract
Transcranial ultrasound therapy has become a non-invasive method for treating neurological and psychiatric disorders, and studies have further demonstrated that multi-target transcranial ultrasound therapy is a better solution. At present, multi-target transcranial ultrasound therapy in small animals can only be achieved by the multi-transducer or phased array. However, multiple transducers may cause spatial interference, and the phased array system is complicated, expensive, and especially unsuitable for small animals. This study is the first to design and fabricate a miniature acoustic holography lens for multi-target transcranial ultrasound therapy in rats. The acoustic holographic lens, working at a frequency of 1.0 MHz, with a size of 10.08 mm × 10.08 mm and a pixel resolution of 0.72 mm, was designed, optimized, and fabricated. The dual-focus transcranial ultrasound generated based on the lens was measured; the full width at half maximum (FWHM) of the focal spots in y-direction were 2.15 and 2.27 mm, respectively, and in z-direction were 2.3 and 2.36 mm, respectively. The focal length was 5.4 mm, and the distance between the two focuses was 5.6 mm, close to the desired values of 5.4 mm and 6.0 mm, respectively. Finally, the multiple-target blood-brain barrier opening in rats' bilateral secondary visual cortex (mediolateral area, V2ML) was demonstrated using the transcranial ultrasound therapy system based on the lens. These results demonstrate the good performance of the multi-target transcranial ultrasound therapy system for small animals, including high spatial resolution, small size, and low cost.
- Published
- 2022