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Significance determination process (SDP) is one of important application tools in the scheme of risk-informed and performance based regulation. It is used to help the analyst evaluate the risk significance of a particular safety concerned event. By referring to the design and development of SDP system, this paper gives a brief introduction on the design and development of the system. An autonomously developed PSA quantification engine is incorporated into the SDP system, and it helps to resolve quantification issue for event risk evaluation. From qualified screening to risk significance quantification, SDP system is designed to realize the whole process for event risk analysis. SDP system could potentially help analysts from both regulatory agency and NPP licensees to quickly evaluate the risk significance of a particular event.

A novel chemiluminescence (CL) animal tissue‐based sensor for pyruvic acid is presented in this paper. Pork heart tissue was chopped into small pieces and packed into a mini‐glass column as the recognition element. When pyruvic acid passed through the column, hydrogen peroxide was produced under the catalytic oxidation of oxygen by pyruvic acid oxidase present in the pork heart tissue. This produced hydrogen peroxide could react with luminol in alkaline solution to produce chemiluminescence in the presence of potassium hexacyanoferrate(III). The developed sensor system promises simplicity, fastness, stability, and sensitivity. Under the optimum conditions, CL intensities are proportional to the concentration of pyruvic acid in the range of 0.02–12 µmol/L, with a detection limit of 0.004 µmol/L (3σ). RSD is 2.3% for 0.5 µmol/L pyruvic acid (n=11). The sensor could be stable for 150 min by more than 100 times determination. The proposed method has been applied successfully to the analysis of pyruvi...

A new chemiluminescence (CL) method is proposed for the determination of quinine sulphate, which is based on the dichloromethane solvent extraction of the ion-pair complex of tetrachloroaurate (III) with quinine sulphate, and luminol CL detection in a reversed micellar medium formed by the cation surfactant cetyltrimethylammonium bromide in a dichloromethane–cyclohexane (3:7, v[sol ]v)–water (0.35 mol[sol ]L Na2CO3 buffer solution, pH 11.5). The ion-pair complex of tetrachloroaurate (III) with quinine sulphate produced an analytical CL signal when it entered the reversed micellar water pool. In optimum conditions, CL intensities are proportional to the concentrations of the studied drug over the range 0.015–10 µg[sol ]mL, with a detection limit of 1.5 ng[sol ]mL. The relative standard deviation (RSD) is 1.38% for 2.5 µg[sol ]mL quinine sulphate (n = 11). The method has been applied to the determination of the studied drug in biological fluids, with satisfactory results. Copyright © 2005 John Wiley & Sons, Ltd.