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A 45-year female presented with a sudden eruption of multiple brownish black nodular lesions since 5 months over the face, trunk and extremities which were clinically diagnosed as a case of nodular malignant melanoma. Histopathologically, they revealed the secondaries from carcinoma rectum.

A 6-year-old male child had linear scaly erythematous band on the penis, undersuface of penis, extending to the scrotum since birth. He was diagnosed clinically as well as histopathologically as a case of naevoid psoriasis.

A 38-year-old male had arthritis since 8 years and erythematous papules, plaques, cutaneous and subcutaneous nodules over face, ears, trunk, and extensors of arms since 2 years, Histopathologically, presence of multiple foreign body giant cells confirmed the clinical diagnosis of multicentric reticulohistiocytosis. Unusual associations were: tapered fingers with depressed scars on their tips, low ESR - (5mm 1st hour). Raynaud′s phenomenon and exaggeration of lesions after methotrexate.

Comparative histopathology was studied in 25 cases of scabies versus 25 cases of nodular scabies which were selected from Dermato-Venereology out patients. Salient differences observed were that in scabies lifting of stratum corneum at places was seen in all 100% cases, spongiosis in 100%, spongiotic vesicles in 28%, burrows in 56%, mite in 40% and vasculitis in 28% whereas in nodular scabies acanthosis was seen in 100%, pseudo epitheliomatous hyperplasia in 8%, burrows in 48%, mite in 24% and vasculitis in 84%. In nodular scabies, dermal infiltrate in 32% cases was arranged as lymphoid follicles with admixture of plasma cells and eosinophils.

102 cases of leprosy were studied clinically and histopathologically according to Ridleyâ€s scale of 1977; 8 odd cases of leprosy where criteria were not exactly fulfilled were excluded. Clinico-histopathological correlation (CHC) was studied in 94/102 cases. CHC was seen in 75/94 (79.7%). 63/102 cases had hypopigmented macules with variable degree of anaesthesia and CHC was seen in 49/63 (77.7%)

One 50 year old female had recurrent vesiculobullous lesions and progressive dysphagia since 3 months. Both complaints started almost simultaneously, although she had dyspepsia and indigestion since 1 year. Histopathology confirmed that she had pemphigus foliaceous ano associated squamous cell carcinoma of oesophagus. The co-existence of pemphigus and malignancy is unusual. The two conditions may be causally related as pemphigus antibodies may lead to production or release of squamous cell carcinoma related antigens. Present case is being reported because of its rare association

Trauma associated with break in continuity of skin results in inocalation of M. leprae at the site of injury with resultant development of inoculation leprosy. The present report records a case of inoculation leprosy after ear-piercing in a 45 year old female with positive smears and borderline lepromatous histopathology, due most probably to systematic steroids.

A 43 year old female had progressive indolent, firm, tender, nodular swellings with multiple sinuses discharging pus containing black granules on left foot and ankle since 3 years. Smear of granule showed dark brown irregular mass with hyphae towards the periphery. Superimposed E. coli infection was treated with cefadroxyl 500 mg B.D Histopathologically marked acanthosis of epidermis , dense collection of mononuclear PMNLâ€s, plasma cells around granules of maduramycosis were seen. X-ray foor showed osteolytic lesions and culture was negative. Satisfactory and progressive improvement occurred after 7 weeks of therapy with ketoconozole 200 mg.

Forty-one cases of psoriatic arthropathy (PA) were selected for the study. Biopsy, x rays of hands, feet, cervical and dorsolumbar spine, sacro-iliac joints and routine investigations were carried out. Clinical diagnosis of psoriasis was confirmed histopathologically. Radiological changes in order of frequency were most common in feet - 26/41, hands - 24/41, sacro-iliac joints -11/41, dorso-lumbar spine - 4/41 and cervical spine - 3/41. Distinctive radiological changes were seen in psoriatic arthritis.

Presence of recurrent herpes labialis with resultant secondary vitiligo associated with recurrent erythema multiforme further leading to depigmentation of skin in relation to target shaped maculopapular lesions in two real sisters was observed as a unique phenomenon which probably has not been reported earlier.

A rare case of nodular colloid degeneration is reported which presented clinically as plaques studded with soft yellow papules simulating adult colloid milia superimposed only on herpes zoster scars of right side of the face.