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Piątek Patrycja, Fabian-Danielewska Anna, Korabiusz Katarzyna, Stecko Monika, Wawryków Agata, Witkiewicz Wojciech, Stachowiak Paweł, Gorący Jarosław. The role of irisin in ischemic heart disease. Journal of Education, Health and Sport. 2019;9(7):30-35. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3265182 http://ojs.ukw.edu.pl/index.php/johs/article/view/7073 https://pbn.nauka.gov.pl/sedno-webapp/works/917033 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.06.2019. Revised: 25.06.2019. Accepted: 30.06.2019. The role of irisin in ischemic heart disease Piątek Patrycja1,2, Fabian-Danielewska Anna1, Korabiusz Katarzyna1, Stecko Monika1, Wawryków Agata1, Witkiewicz Wojciech1,2, Stachowiak Paweł2, Gorący Jarosław2 ¹ Pomeranian Medical University in Szczecin, Doctoral Studies ² Pomeranian Medical University in Szczecin, Independent Laboratory of Invasive Cardiology Key words: irisin; ischemic heart disease; metabolizm Abstract: Introduction: Physical effort has a positive effect on the human body, through its protective effect on the development of many diseases, along with cardiovascular system diseases. Irisin is an adipomiokine that is a fragment of the doemeny of extracellular FNDC5 protein. It is released from FNDC5 due to physical activity and peroxisome proliferator receptor-γ coactivator 1α (PGC-1α) stimulation. It forms a link between the muscles and other tissues of the body. Moreover, it affects the conversion of white adipose tissue into brownish-like fat tissue. Aim: For over 15 years ischemic heart disease has been one of the most common causes of death in the world. Therefore, attempts have been made to clarify the role it has in ischemic heart disease. Conclusions: It has been proven, that the concentration of irisin decreases in patients with myocardial infarction it also correlates with the severity of stable coronary disease and a higher SYNTAX score. Hence, the hypothesis was that the level of this protein probably depends on the inflow of blood to the myocardium. It can therefore be used for the panel of myocardial damage. The New Approach of therapeutic options uses irisin with stem cells during the repairing of myocardium. Despite much interest in irisin, there are still many questions that need to be answered, in particular those related to the irisin cell receptor and what is related to the clarification of its mechanisms in physiology.