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3 results on '"Franz B Frenzel"'

1. Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis

Author

Sine Godiksen, Helle Høyer, Tine Iskov Kopp, Ulla Vogel, Franz B. Frenzel, Julian Hamfjord, Inger Marie Bowitz-Lothe, Mona Sæbø, Egil Johnson, Vibeke Andersen, Elin H. Kure, and Lotte K. Vogel

Subjects
Male, Colorectal cancer, Epidemiology, Carcinogenesis, lcsh:Medicine, Gastroenterology, Gastrointestinal Cancers, Medicine and Health Sciences, Clinical Epidemiology, Intestinal Mucosa, lcsh:Science, Immune Response, Multidisciplinary, Cancer Risk Factors, Middle Aged, CYCLOOXYGENASE-2 EXPRESSION, CANCER, Intestines, Oncology, CARCINOMAS, NSAID USE, Adenocarcinoma, Female, Colorectal Neoplasms, Cancer Epidemiology, Research Article, CHEMOPREVENTION, Adenoma, medicine.medical_specialty, Genotype, Immunology, Genetic Causes of Cancer, Gastroenterology and Hepatology, Biology, SDG 3 - Good Health and Well-being, Internal medicine, ADENOMAS, Gastrointestinal Tumors, medicine, Genetics, Cancer Genetics, Humans, RNA, Messenger, Allele, METAANALYSIS, Alleles, Aged, Inflammation, Clinical Genetics, Polymorphism, Genetic, Haplotype, lcsh:R, Case-control study, Immunity, Biology and Life Sciences, Cancers and Neoplasms, Odds ratio, COX-2, medicine.disease, digestive system diseases, Biomarker Epidemiology, Dysplasia, Cyclooxygenase 2, Case-Control Studies, RISK-FACTORS, lcsh:Q, Clinical Immunology, MULTIDISCIPLINARY, INFLAMMATORY-BOWEL-DISEASE
Abstract

BACKGROUND & AIMS: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation.METHODS: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort.RESULTS: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (PCONCLUSION: High intestinal PTGS2 mRNA level is an early event in colorectal cancer development as it occurs already in mild/moderate dysplasia. PTGS2 polymorphisms that have been associated with altered PTGS2 mRNA levels/COX-2 activity in some studies, although not the present study, were associated with colorectal cancer risk. Thus, both PTGS2 polymorphisms and PTGS2 mRNA levels may provide information regarding CRC risk.

Published
2014

3. Low ABCB1 Gene Expression Is an Early Event in Colorectal Carcinogenesis

Author

Lotte K. Vogel, Vibeke Andersen, Mona Sæbø, Sine Godiksen, Franz B. Frenzel, Ulla Vogel, Julian Hamfjord, and Elin H. Kure

Subjects
Male, Health Screening, Anatomy and Physiology, Carcinogenesis, Colorectal cancer, Digestive Physiology, Gene Expression, lcsh:Medicine, medicine.disease_cause, INDEL Mutation, Molecular Cell Biology, Gastrointestinal Cancers, Genotype, Gene expression, lcsh:Science, Multidisciplinary, Colonoscopy, Middle Aged, Medicine, Female, Public Health, Colorectal Neoplasms, Research Article, Adenoma, Cell Physiology, medicine.medical_specialty, ATP Binding Cassette Transporter, Subfamily B, Colon, Gastroenterology and Hepatology, Biology, Polymorphism, Single Nucleotide, Internal medicine, Genetics, Carcinoma, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, RNA, Messenger, Genetic Testing, Clinical Genetics, Population Biology, lcsh:R, Personalized Medicine, Case-control study, NF-kappa B p50 Subunit, Endoscopy, medicine.disease, Molecular biology, Endocrinology, Dysplasia, Case-Control Studies, Genetic Polymorphism, lcsh:Q, Physiological Processes, Digestive System, Population Genetics
Abstract

The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P

Published
2013

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