1. Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis
- Author
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Sine Godiksen, Helle Høyer, Tine Iskov Kopp, Ulla Vogel, Franz B. Frenzel, Julian Hamfjord, Inger Marie Bowitz-Lothe, Mona Sæbø, Egil Johnson, Vibeke Andersen, Elin H. Kure, and Lotte K. Vogel
- Subjects
Male ,Colorectal cancer ,Epidemiology ,Carcinogenesis ,lcsh:Medicine ,Gastroenterology ,Gastrointestinal Cancers ,Medicine and Health Sciences ,Clinical Epidemiology ,Intestinal Mucosa ,lcsh:Science ,Immune Response ,Multidisciplinary ,Cancer Risk Factors ,Middle Aged ,CYCLOOXYGENASE-2 EXPRESSION ,CANCER ,Intestines ,Oncology ,CARCINOMAS ,NSAID USE ,Adenocarcinoma ,Female ,Colorectal Neoplasms ,Cancer Epidemiology ,Research Article ,CHEMOPREVENTION ,Adenoma ,medicine.medical_specialty ,Genotype ,Immunology ,Genetic Causes of Cancer ,Gastroenterology and Hepatology ,Biology ,SDG 3 - Good Health and Well-being ,Internal medicine ,ADENOMAS ,Gastrointestinal Tumors ,medicine ,Genetics ,Cancer Genetics ,Humans ,RNA, Messenger ,Allele ,METAANALYSIS ,Alleles ,Aged ,Inflammation ,Clinical Genetics ,Polymorphism, Genetic ,Haplotype ,lcsh:R ,Case-control study ,Immunity ,Biology and Life Sciences ,Cancers and Neoplasms ,Odds ratio ,COX-2 ,medicine.disease ,digestive system diseases ,Biomarker Epidemiology ,Dysplasia ,Cyclooxygenase 2 ,Case-Control Studies ,RISK-FACTORS ,lcsh:Q ,Clinical Immunology ,MULTIDISCIPLINARY ,INFLAMMATORY-BOWEL-DISEASE - Abstract
BACKGROUND & AIMS: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation.METHODS: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort.RESULTS: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (PCONCLUSION: High intestinal PTGS2 mRNA level is an early event in colorectal cancer development as it occurs already in mild/moderate dysplasia. PTGS2 polymorphisms that have been associated with altered PTGS2 mRNA levels/COX-2 activity in some studies, although not the present study, were associated with colorectal cancer risk. Thus, both PTGS2 polymorphisms and PTGS2 mRNA levels may provide information regarding CRC risk.
- Published
- 2014