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Portable devices play an essential role where edge computing is necessary and mobility is required (e.g., robots in agriculture within remote-sensing applications). With the increasing applications of deep neural networks (DNNs) and accelerators for edge devices, several methods and applications have been proposed for simultaneous crop and weed detection. Although preliminary studies have investigated the performance of inference time for semantic segmentation of crops and weeds in edge devices, performance degradation has not been evaluated in detail when the required optimization is applied to the model for operation in such edge devices. This paper investigates the relationship between model tuning hyperparameters to improve inference time and its effect on segmentation performance. The study was conducted using semantic segmentation model DeeplabV3 with a MobileNet backbone. Different datasets (Cityscapes, PASCAL and ADE20K) were analyzed for a transfer learning strategy. The results show that, when using a model hyperparameter depth multiplier (DM) of 0.5 and the TensorRT framework, segmentation performance mean intersection over union (mIOU) decreased by 14.7% compared to that of a DM of 1.0 and no TensorRT. However, inference time accelerated dramatically by a factor of 14.8. At an image resolution of 1296 × 966 , segmentation performance of 64% mIOU and inference of 5.9 frames per second (FPS) was achieved in Jetson Nano's device. With an input image resolution of 513 × 513 , and hyperparameters output stride OS = 32 and DM = 0.5, an inference time of 0.04 s was achieved resulting in 25 FPS. The results presented in this paper provide a deeper insight into how the performance of the semantic segmentation model of crops and weeds degrades when optimization is applied to adapt the model to run on edge devices. Lastly, an application is described for the semantic segmentation of weeds embedded in the edge device (Jetson Nano) and integrated with the robotic orchard. The results show good spraying accuracy and feasibility of the method. [ABSTRACT FROM AUTHOR]