Dear Editor, Erosive pustular dermatosis of the leg (EPDL) is a rare inflammatory cutaneous disease characterized by nonfollicular sterile pustules, erosions and crusts on an erythematous background.[1] EPDL generally affects the middle third of the leg, typically in elderly patients. Indeed, 10 out of 23 patients (43%) in the TC-only group relapsed, whereas four out of 28 patients (14%) treated with both TC and topical zinc oxide relapsed. On the basis of our results, topical zinc oxide may represent a valid, easy and cheap therapeutic strategy for maintenance therapy of EPDL, after TCs have achieved their anti-inflammatory role in the acute phase. [Extracted from the article]