1. Sweet tea leaves extract improves leptin resistance in diet-induced obese rats.
- Author
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Zhou CJ, Huang S, Liu JQ, Qiu SQ, Xie FY, Song HP, Li YS, Hou SZ, and Lai XP
- Subjects
- Adiponectin metabolism, Adipose Tissue drug effects, Adipose Tissue metabolism, Animals, Blood Glucose drug effects, Body Weight drug effects, C-Reactive Protein metabolism, CCAAT-Binding Factor biosynthesis, Diet, High-Fat, Disease Models, Animal, Dose-Response Relationship, Drug, Drugs, Chinese Herbal chemistry, Drugs, Chinese Herbal pharmacology, Gene Expression drug effects, Insulin metabolism, Insulin pharmacology, Insulin Resistance, Lipid Metabolism drug effects, Male, Malondialdehyde metabolism, Obesity blood, PPAR gamma biosynthesis, Plant Leaves chemistry, Rats, Rats, Sprague-Dawley, Resistin metabolism, Superoxide Dismutase metabolism, Beverages, Drugs, Chinese Herbal therapeutic use, Fagaceae chemistry, Leptin metabolism
- Abstract
Aim of the Study: Dietary obesity is usually characterized by leptin resistance and abnormal lipid metabolism. Lithocarpus polystachyus Rehd.(Sweet Tea) leaf is a kind of Chinese folkloric medicine, and it has been widely used for obesity, diabetes, and hypertension in South China. The present study is aimed at investigating the pharmacological mechanism of the anti-hyperleptinaemia effects of Sweet Tea leaves extract in high fat diet-induced obese rats., Materials and Methods: We induced high fat diet obesity for 14 weeks to test the corrective effects of three ST doses (75, 150 and 300 mg/kg per day) for 8 weeks. At the end of the experiment, body weight, fasting blood glucose and serum lipids, superoxide dismutase (SOD), malondialdehyde (MDA), fasting serum insulin and leptin, C-reactive protein, adiponectin and resistin levels were measured, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) was also calculated. mRNA gene expression of PPARγ (peroxisome proliferator-activated receptor γ) and C/EBPα(CCAAT/enhancer-binding protein α) in epididymal adipose tissue of DIO control and experimental groups were evaluated., Results: Sweet Tea leaves extract could significantly decrease the levels of serum lipids, attenuate body weight gain and lower circulating leptin and insulin levels, ameliorate the state of oxidative stress, raise serum adiponectin, reduce circulating CRP and resistin levels, and depress the expression of PPARγ and C/EBPα in epididymal adipose tissue of obese rats., Conclusion: The present findings suggest that ST can effectively attenuate the leptin resistance at least through anti-hyperlipidemic activity and thus has the therapeutic potential in treating hyperlipidemia and hyperleptinaemia related to dietary obesity., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
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