1. A review of the implication of hypoxanthine excess in the physiopathology of Lesch-Nyhan disease.
- Author
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Torres RJ, Prior C, Garcia MG, and Puig JG
- Subjects
- Adenosine metabolism, Biological Transport, Cell Differentiation, Homeodomain Proteins genetics, Homeodomain Proteins metabolism, Humans, Lesch-Nyhan Syndrome physiopathology, Lesch-Nyhan Syndrome psychology, Neurons physiology, Wnt4 Protein genetics, Wnt4 Protein metabolism, Hypoxanthine physiology, Lesch-Nyhan Syndrome metabolism
- Abstract
Lesch-Nyhan disease is caused by HGprt deficiency, however, the mechanism by which enzyme deficiency leads to the severe neurological manifestations is still unknown. We hypothesized that hypoxanthine excess leads, directly or indirectly, through its action in adenosine transport, to aberrations in neuronal development. We found that hypoxanthine diminishes adenosine transport and enhances stimulation of adenosine receptors. These effects cause an imbalance between adenosine, dopamine, and serotonin receptors in HGprt deficient cells, and cells differentiated with hypoxanthine showed an increase in dopamine, adenosine and serotonin receptors expression. Hypoxanthine deregulates early neuronal differentiation increasing WNT4 and EN1 gene expression.
- Published
- 2016
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