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Your search keyword '"Muscle Cramp psychology"' showing total 2 results
Start Over Descriptor "Muscle Cramp psychology" Topic leukemia, myelogenous, chronic, bcr-abl positive
2 results on '"Muscle Cramp psychology"'

1. Chronic fatigue is the most important factor limiting health-related quality of life of chronic myeloid leukemia patients treated with imatinib.

Author

Efficace F, Baccarani M, Breccia M, Cottone F, Alimena G, Deliliers GL, Baratè C, Specchia G, Di Lorenzo R, Luciano L, Turri D, Martino B, Stagno F, Dabusti M, Bergamaschi M, Leoni P, Simula MP, Levato L, Fava C, Veneri D, Sica S, Rambaldi A, Rosti G, Vignetti M, and Mandelli F

Subjects
Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Cross-Sectional Studies, Fatigue Syndrome, Chronic psychology, Female, Health Surveys, Humans, Imatinib Mesylate, Leukemia, Myelogenous, Chronic, BCR-ABL Positive psychology, Male, Middle Aged, Multivariate Analysis, Muscle Cramp complications, Muscle Cramp psychology, Musculoskeletal Pain complications, Musculoskeletal Pain psychology, Social Behavior, Young Adult, Benzamides therapeutic use, Fatigue Syndrome, Chronic complications, Leukemia, Myelogenous, Chronic, BCR-ABL Positive complications, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Piperazines therapeutic use, Pyrimidines therapeutic use, Quality of Life
Abstract

Health-related quality of life (HRQOL) is an important goal of therapy for chronic myeloid leukemia (CML) patients treated with current molecular-targeted therapies. The main objective of this study was to investigate factors associated with long-term HRQOL outcomes of CML patients receiving imatinib. Analysis was performed on 422 CML patients recruited in an observational multicenter study. HRQOL was assessed with the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Key socio-demographic and clinical data were investigated for their association with HRQOL outcomes. Chronic fatigue and social support were also investigated. Univariate and multivariate linear regression analyses were used to identify independent factors associated with HRQOL outcomes. Fatigue was the only variable showing an independent and consistent association across all physical and mental HRQOL outcomes (P<0.01). Differences between patients reporting low versus high fatigue levels were more than eight and seven times the magnitude of a clinically meaningful difference, respectively, for the role physical (Δ=70 points) and emotional scale (Δ=63 points) of the SF-36. Fatigue did not occur as an isolated symptom and was most highly correlated with musculoskeletal pain (r=0.511; P≤0.001) and muscular cramps (r=0.448; P≤0.001). Chronic fatigue is the major factor limiting HRQOL of CML patients receiving imatinib.

Published
2013
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2. Which health-related quality of life aspects are important to patients with chronic myeloid leukemia receiving targeted therapies and to health care professionals? GIMEMA and EORTC Quality of Life Group.

Author

Efficace F, Breccia M, Saussele S, Kossak-Roth U, Cardoni A, Caocci G, Chie W, Naeem A, Nicolatou-Galitis O, Cocks K, Vignetti M, Baccarani M, Mandelli F, and Sprangers M

Subjects
Adult, Aged, Aged, 80 and over, Anxiety, Benzamides, Edema etiology, Edema psychology, Europe, Fatigue etiology, Fatigue psychology, Female, Humans, Imatinib Mesylate, Iraq, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Male, Middle Aged, Muscle Cramp etiology, Muscle Cramp psychology, Social Support, Surveys and Questionnaires, Taiwan, Young Adult, Antineoplastic Agents therapeutic use, Health Personnel psychology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive psychology, Molecular Targeted Therapy psychology, Patients psychology, Piperazines therapeutic use, Protein Kinase Inhibitors therapeutic use, Pyrimidines therapeutic use, Quality of Life
Abstract

The objective of this study was to investigate the health-related quality of life (HRQOL) aspects valued the most by patients with chronic myeloid leukemia (CML) receiving targeted therapies (TT), and to compare their perception with that of health-care professionals' (HCPs). Semi-structured interviews were conducted with 137 CML patients receiving TT from five different countries. An additional sample of 99 CML patients, completing an online interview, was considered for supportive analyses. A sample of 59 HCPs from 12 countries also participated in the study. Patients and HCPs were asked to rate and rank the importance of a predefined list of 74 HRQOL aspects of potential relevance for CML patients. Patients and HCPs agreed that the following five aspects are most important: fatigue, muscle cramps, swelling, worries, and uncertainty about health condition in the future, and importance of social support in coping with the disease. However, the difference in rankings between the two groups was substantial with respect to other HRQOL aspects investigated. Patients valued some issues related to symptoms much higher than HCPs, thus suggesting that a better symptom management could be the crucial aspects to improve HRQOL of CML patients.

Published
2012
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