1. [Clinical and genetics characteristics of patients with monosomal karyotype acute myeloid leukemia patients].
- Author
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Cheng F, Ma X, Pan J, Wu Y, Zhang J, Xue Y, Wang Q, Yao H, Wen L, Shen Y, and Chen S
- Subjects
- Adult, Aged, Chromosomes, Human, Pair 7 genetics, Female, Humans, Karyotype, Male, Middle Aged, Young Adult, Leukemia, Myeloid, Acute genetics, Monosomy
- Abstract
Objective: To investigate the clinical and genetics characteristics of patients with monosomal karyotype acute myeloid leukemia (MK-AML)., Methods: The karyotypes of 3743 patients with newly-diagnosed de novo AML were analyzed, which had identified 153 cases with MK-AML, for whom the clinical and genetics characteristics were analyzed., Results: There were 2056 patients (54.9%) among all patients. A total of 153 patients fulfilling the criteria for MK-AML were identified, which comprised 93 males and 60 females, with a median age of 54. The median white blood cell count on presentation was 4.4×10 (9)/L. One hundred and forty-five cases (94.8%) have fulfilled the criteria for complex karyotype (≥ 3 chromosomal abnormalities). Although the monosomy could be found with all autosomes, chromosome 7 has been most frequently involved (38.56%, 59/153)., Conclusion: MK-AML is a distinct cytogenetic subtype of AML. Monosomy 7 is frequently detected among MK-AML patients. The monosomal karyotype is common among elder patients with AML.
- Published
- 2014
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