1. Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.
- Author
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Yaguchi T, Nagata T, Mukasa T, Fujikawa H, Yamamoto H, Yamamoto S, Iso H, Tanaka A, and Nishizaki T
- Subjects
- Aging genetics, Animals, Avoidance Learning drug effects, Behavior, Animal drug effects, Disease Models, Animal, Exploratory Behavior drug effects, Learning Disabilities etiology, Male, Maze Learning drug effects, Mice, Mice, Neurologic Mutants, Motor Activity drug effects, Reaction Time drug effects, Aging physiology, Caprylates therapeutic use, Learning Disabilities drug therapy, Linoleic Acid chemistry
- Abstract
In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the open-field test to assess motor activity, it was confirmed that the DCP-LA effect is not due to increased motor activity. In the passive avoidance test to assess fear memory, DCP-LA had no effect on the latency of acquisition and retention for SAMP8. The results of the present study, thus, suggest that DCP-LA could improve age-related learning impairment by enhancing cognitive functions.
- Published
- 2006
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