1. AVALIAÇÃO IN VITRO DA INFLUÊNCIA DA FUMAÇA DE CIGARRO EM LEUCÓCITOS HUMANOS.
- Author
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von Brock de Freitas, José Paulo, de Oliveira Souza, Raul, Mansur Machado, Michel, and Souza de Oliveira, Luís Flávio
- Abstract
Smoking is the leading cause of preventable death worldwide, according to the World Health Organization (WHO). It is estimated that one-third of adult worldwide population, that is, 1.2 billion people are smokers. Because of this, it is relevant to evaluate the damage caused by exposure to cigarette smoke, which includes different cellular types. In line with this, the present study assessed in vitro the cytotoxic effect and peroxidation levels of human leukocytes exposed to cigarette smoke simulating a closed environment for smokers, through the cellular viability test and TBARS. The results found showed that all cigarette trademarks tested caused a significant decrease in leukocyte viability and an increase in the malondialdehyde concentration, when compared to the negative control. However, this cell viability decrease cannot be attributed solely to the lipid peroxidation levels, but possibly to the set of compounds found in cigarette smoke, some of these stated on the label thereof. [ABSTRACT FROM AUTHOR]
- Published
- 2016