Search

Background: Infantile acne refers to a skin disease that usually occurs on the face from 6 weeks to 1 year old, and the etiology of infantile acne is different from that of puberty acne. The change of skin surface lipid (SSL) is an important factor in the occurrence of acne., Objectives: Comparison of facial skin lipid changes in healthy and acne-prone infants, screening for possible groupings of substances, to explore factors associated with the development of acne in infants, such as gender and frequency of face washing., Methods: A questionnaire was used to obtain information about the infant, facial lipids were affixed with adhesive tape, and the samples were analyzed using Ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS), with subsequent data analyzed by single-factor and multifactor analysis., Results: It was observed that some lipids followed the trend of lipid master classes, subclasses and were significantly different. Galactosylceramides, glycosylceramides and phosphatidylethanolamine were screened as the majority of differentiating lipid species. Additionally, it was emphasized that the frequency of face washing and parent's acne was independent with the severity of acne in infant by clinical characteristics, whereas the skin type and gender can affect the severity of acne statistically., Conclusions: Facial lipids change significantly between infantile acne and healthy infants, suggesting that qualitative and quantitative changes in lipids are strongly associated with the development of acne and may exacerbate the environment in which acne occurs., (© 2020 Wiley Periodicals LLC.)

Background: Acne is a multifactorial skin disorder frequently observed during adolescence with different grades of severity. The crucial factors of acne are the increase of lipids secretion and the change of composition on the skin surface lipid (SSL). However, there are no studies on the changes of lipid composition and content between different grades of adolescent acne in lesional skin and nonlesionsal skin., Aims: This study was to investigate correlation in the composition of SSL and different grades in order to understand the tendency of SSL alterations in this disease for successful acne management and prevention., Methods: A powerful analytical technique, UPLC-QTOF-MS, and multivariate data analysis were used to investigate SSL variations of lipid main classes, subclasses, and species., Results: The results indicated that sphinganine, triradylglycerols (TG), and phytosphingosine were important in adolescent acne development. The average fatty acids (FAs) chain length in patients with acne showed significantly shortened trend from mild to moderate adolescent acne. Additionally, the relative average content of TG, diglyceride (DG), FA, ceramides (Cers), and the level of unsaturated FAs significantly increased from mild to moderate adolescent acne. Interestingly, our results demonstrated that the phytosphingosine and sphinganine showed an increasing trend in mild acne groups, but decreasing trend in lesional skin of moderate group., Conclusions: Lipidomics analysis suggested that the variation of TG, phytosphingosine, and sphinganine was closely related to the occurrence severity of acne in adolescent., (© 2020 Wiley Periodicals, Inc.)

Background: Regional differences in skin characteristics are well known. Significant differences in skin physiology between the forehead and cheek have also been reported. However, there are few studies based on lipidomics at the molecular level. Additionally, there is no study focusing on the lipid profile variations of skin surface lipid (SSL) in forehead and cheek., Purpose: This study analyzed the differences in facial SSL between forehead and cheek of men aged 18-25 years to explain the distinct physiological parameters between forehead and cheek resulting in different skin status., Methods: Facial SSL was identified by ultra-performance liquid chromatography-quadrupole time of flight-mass spectrometry (UPLC-QTOF-MS). Multivariate data analysis was used to investigate the SSL difference in forehead and cheek., Results: Significant differences in facial SSL composition were detected between the forehead and cheek. Multivariate data analysis suggested that 21 entities contributed most significantly toward the discrimination and phosphatidylserines (PS) constituted the majority of differentiating lipid species. Subsequent analysis showed a marked increase in the amounts of unsaturated and saturated free fatty acids (FFAs), and a significant increase in average FFAs chain length in the forehead as compared to that in the cheek., Conclusions: Phosphatidylserines exposure might be one of the most important reasons for the increased amount of forehead SSL secretion. The different FFAs chain length and FFAs content lead to altered skin barrier functions in forehead and cheek, consequently resulting in altered trans-epidermal water loss (TEWL) and pH at the two anatomical sites., (© 2020 Wiley Periodicals, Inc.)

Background: Neonatal acne occurs in the first few weeks after birth. Some lesions are more serious and leave scars. Maternal surface skin lipids (SSL) have a strong correlation with SSL of infants. The establishment of prediction rank model based on maternal SSL is essential to the prevention and treatment of neonatal acne., Method: Surface skin lipids samples were collected from the mothers (M) of 56 neonatal acne patients and the mothers (HM) of 19 healthy infants. Surface skin lipids from the right forehead were collected using a noninvasive method. UPLC-QTOF-MS was applied to detect SSL. Partial least squares discriminant analysis and receiver operating characteristic (ROC) analysis were performed to screen and validate potential lipids. Random forest (RF) and ROC analysis were used to establish a prediction model and evaluate its accuracy., Results: Sixteen altered potential lipids belonging to fatty acids, sphingomyelins, and glycerides were associated with M. M had less lipids than HM. Spearman's correlation of 16 lipids revealed 9 with high correlation. They were chosen as characteristic values of the RF prediction model. And the model showed an average accuracy of 98% in the validation set., Conclusion: We have established an RF model for predicting neonatal acne and have shown that high skin barrier-related lipids were markers for predicting neonatal acne., (© 2020 Wiley Periodicals, Inc.)

Background: The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at the physiological level; however, few studies at the molecular level have been reported. Additionally, there is no study on lipidomic profile variations of skin surface lipid (SSL), which could potentially explain the rhythmic changes in skin status. Objectives: The SSL profile of healthy young women was analysed to assess SSL variations and to assess the skin status during the circadian cycle. Methods: Ultra performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry and multivariate data analysis were performed to assess SSL variations. Results: The lipidomic profile showed significant differences with the circadian rhythm. Multivariate data analysis indicated that glycerolipids were the lipids majorly affected by the circadian rhythm. Additionally, in the SSL profile, both the average chain length and the content of free fatty acids (FFAs) were higher at 20:00 than at 08:00. Conclusions: The SSL profile significantly varied with respect to the circadian rhythm. The rhythm‐altered triacylglycerol level, FFA chain length and FFA content resulted in rhythmic changes in skin barrier function, including transepidermal water loss alteration and pH variation. [ABSTRACT FROM AUTHOR]