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Start Over Author "Baošić, Rada" Topic lipophilicity
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4. Polidentatne Šifove baze i njihovi Cu(II) kompleksi: lipofilnost i biološka aktivnost

Author

Stevanović, Nikola R., Baošić, Rada, Zlatović, Mario, Apostolović, Danijela, Stanković, Slaviša, and Aranđelović, Sandra

Subjects
antikancerska aktivnost, antimicrobial activity, antimikrobna aktivnost, HSA, molecular docking, Schiff base, anticancer activity, lipofilnost, binding affinity, lipophilicity, cytotoxicity, citotoksičnost, Šifove baze, molekulski doking
Abstract

Šifove baze i njihovi kompleksi pokazuju različitu biološku aktivnost poput antiviralne, antimikrobne, antimalarijske i antikancerske. Zbog činjenice da biološka aktivnost jedinjenja zavisi prvenstveno od lipofilnosti molekula, što je posledica strukture jedinjenja, određivanje i korelacija lipofilnosti sa hemijskom strukturom, kao i određivanje biološke aktivnosti su postali nezaobilazni u sintezi novih lekova... Schiff bases and their complexes are versatile compounds which have various biological activities such as antiviral, antimicrobial, antimalarial, and anticancer activity. Biological activity of compounds depends on their molecular structure, especially lipophilic character. Determination of lipophilicity, its correlation with chemical structure, and biological activity is very important in drug design...

Published
2018

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