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Your search keyword '"Li, Qiu-Rong"' showing total 2 results
Start Over Author "Li, Qiu-Rong" Topic lipopolysaccharide
2 results on '"Li, Qiu-Rong"'

2. Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia

Author

Feng, Ai-Wen, Yu, Chao, Mao, Qing, Li, Ning, Li, Qiu-Rong, and Li, Jie-Shou

Subjects
*ENDOTOXEMIA prevention, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *BIOPHYSICS, *CELL receptors, *INTESTINAL mucosa, *SMALL intestine, *RESEARCH methodology, *MEDICINAL plants, *RATS, *PLANT extracts
Abstract

Abstract: The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased phosphorylation of mucosal p38 MAPK and ATF2 as well as production of ATF2, whereas BBR attenuated these effects. LPS upregulated mucosal peroxisome proliferator-activated receptor gamma (PPARγ), but BBR reduced this receptor. GW9662 aggravated LPS-induced and reversed BBR-attenuated COX-2 expression. The findings showed that BBR ameliorated COX-2 overexpression partially via modulation of p38 and PPARγ pathways during acute endotoxemia. [Copyright &y& Elsevier]

Published
2011
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