1. Formulation and Characterization of Docetaxel-Loaded Microsponge-Based Hydrogel for Basal Cell Carcinoma.
- Author
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Kotnala, Mohit, Sethi, Pranshul, Mandal, Suraj, Chaudhary, Aditi, Iliger, Sudhir R., Singh, Nitish Kumar, Kar, Nihar Ranjan, and Mishra, Sruti Ranjan
- Subjects
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BASAL cell carcinoma , *SKIN cancer , *HYDROGELS , *SODIUM alginate , *HYALURONIC acid , *LIPOSOMES - Abstract
Researchers wanted to develop skin liposomal formulations that would carry 5-fluorouracil to the cancer site in an adjuvant way, as well as enhancing the health of basal cell carcinoma patients who were experiencing unfavorable consequences. Using Strat-M films in vitro, the detailed skin-damaging potential of the synthesized skin liposomes and the sensitivity to 5-fluorouracil were evaluated. It was found that the Korsmeyer-Pepas condition was the best one for controlling drug administration. Additionally, it is unknown if it might irritate skin. The vitality and hemolytic potential of the cytostatic effect on the recommended anti-tumor therapy were also examined in in vitro investigations. Our findings suggest that a sodium alginate and hyaluronic acid crosslinked gel containing AS1411 aptamer liposomes coated with 5-fluorouracil is the optimal liposome solution. This liposome characterization appears to have good biological safety implications and may be exploited as a different approach to basal cell carcinoma skin treatments. [ABSTRACT FROM AUTHOR]
- Published
- 2023