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Background: Harlequin ichthyosis (HI) is the most severe phenotype of autosomal recessive congenital ichthyosis. Juvenile Idiopathic Arthritis (JIA) represents a heterogenous group of disorders all sharing the clinical manifestation of chronic arthritis. Association of HI and chronic arthritis has been reported in few cases. Case presentation: We report the case of a child with HI who developed a severe form of chronic polyarthritis during the first years of life, treated with repeated multiple joint injections, methotrexate and etanercept with good response and without any adverse events. Conclusion: The reported case and the literature review highlighted the presence of a peculiar severe seronegative polyarthritis with early onset in a series of patients with HI, suggesting that polyarthritis may be a specific manifestation of HI, rather than a rare combination of two separate conditions. [ABSTRACT FROM AUTHOR]

The incorrect author name is: Stefani Lanni The correct author name is: Stefano Lanni The author group has been updated above and the original article [[1]] has been corrected. B Correction to: Pediatr Rheumatol 19, 80 (2021) b B https://doi.org/10.1186/s12969-021-00571-9 b Following publication of the original article [[1]], the authors identified an error in the author name of Stefano Lanni. Reference 1 Baldo F, Brena M, Carbogno S. Juvenile idiopathic arthritis in Harlequin ichthyosis, a rare combination or the clinical spectrum of the disease?. [Extracted from the article]