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We have studied the effects of the extract from the dry pomace of honeysuckle fruits Lonicera edulis Turcz. and commercial reference preparation Legalon on weight and biochemical liver indexes in rats upon carbon tetrachloride intoxication. The extract of honeysuckle fruits favored a decrease in the total lipid content, reduced specific liver weight, and facilitated restoration of the activity of serum alanine aminotransferase and liver lysosomal enzymes. It the blood of rats, the extract increased superoxide dismutase activity, decreased glutathione level, enhanced antiradical activity, and reduced the level of malonic dialdehyde. The effect of administration of honeysuckle fruits pomace extract on restoration of the liver function was more pronounced than the effect of Legalon.

Hepatoprotective properties of ethanol extract from the roots of Maackia amurensis Ruper et Maxim have been studied on the model of toxic hepatitis induced by carbon tetrachloride damage. It is established that the extract contains daidzein, 7-O-gentobiosides of isoflavonoids genistein, formononetin, pseudobabtige-nin, and 5-O-methylgenistein, and 3-O-gentobiosides of pterocarpans (6aR, 11aR)-maakiain and (6aR, 11aR)-medicarpin. The administration of extract facilitates the restoration of antioxidant protection enzymes activity and reduced glutathione level, decreases the formation of toxic peroxidation products, produces normalizing impact on liver phospholipid pattern, and improves the erythrocyte tolerance to hemolytic agents. The action of isoflavonoids from Maackia amurensis in restoration of metabolic pathways of the liver and removal of toxic stress was more effective as compared to that of the reference hepatoprotector legalon.

The effect of an extract from tunic of the sea hydrobiont purple ascidium (Halocynthia aurantium) on the lipid metabolism in the liver of mice has been studied under the acute stress conditions modeled by fixing animals for 22 h at the dorsal neck fold. The extract from purple ascidium tunic is superior to essentiale (well-known commercial hepatoprotector) in the efficacy of restoring lipid fraction content (tryglycerides, cholesterol, free fat acids, lysophospholipids) disturbed by stress action. In addition, the extract normalizes the esterification function of the liver. The observed effect of the purple ascidium tunica extract is related to a combined action of the "marine" phospholipids that are present in the preparation and are known to possess reparative properties.

An oligomer proantocyanidine complex (OPCC) isolated from the aqueous-and-alcoholic extract Kalifen and a polyphenol complex (PPC) isolated from the eleutherococcus extract were tested for their effects on carbohydrate and lipid metabolism in the rat liver under acute stress caused by hanging up of the animals by the cervical fold for 22 hours. This acute stress was accompanied by decreases in aerobic glycolysis and pentose cycle and by an increase in lipolysis. Hepatic etherifying function impaired. Lipids became predominant energy substrates. The administration of OPCC and PPC during stress promoted the preservation of carbohydrate metabolic reactions (gluconeogenesis, pentosephosphate pathway, Krebs cycle) and to the decrease of lipolysis. OPCC was shown to have stress-protective properties and to be able to diminish adrenal hypertrophy, to increase the production of oxidized equivalents (NAD+), and to enhance the activity of G-6-PDH in the rat liver. The complex is superior to the well-known antistress agent eleutherococcus, which makes it possible to regard these drugs as possible promising drugs in preventive and rehabilitative medicine.

The paper deals with the study of the preventive effect of the plant drug Korrda-K on lipid and carbohydrate metabolism in the liver of the rat exposed to acetone inhalation. The agent was found to have hepatic and membranous protective effects. On exposure to acetone, Korrda-K promotes the normalization of blood glucose levels and other biochemical parameters. The magnitude of changes in the composition of lipids and fatty acids suggests that the preventive use of the agent favours the preservation of the membrane structure of hepatocytes changed by acetone.

Hepatoprotective effect of natural substances obtained from extracts of grape combs, leaves of green and black tea were studied in liver tissue of ethanol-consuming rats by means of evaluation of the neutral lipid fractions and phospholipids as well as by measurement of glucose and nicotinamide coenzymes NAD+ and NADP in blood. In all the animal groups treated with these vegetable extracts content of total phospholipids, decreased after the ethanol treatment, was increased, while fraction composition of phospholipids and of neutral lipids was normalized; in blood content of glucose, NAD+ and NADP approached to control values. These results suggest that the vegetable extracts studied exhibited the hepatoprotective effect in alcohol intoxication.